Study of methoxy-group position influence on compound alm-802 cardiotropic activity
A new compound ALM-803 (trihydrochloride N1-(3,4,5-trimethoxybenzyl)-N2-{2-[(3,4,5-trimethoxybenzyl)amino]ethyl}-1,2-ethanediamine) was synthesized as analog of ALM 802, differing from it by the position of the methoxy groups in the phenyl rings. It is established that this structural change leads t...
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| Format: | Article |
| Language: | Russian |
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LLC “Publisher OKI”
2019-01-01
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| Series: | Фармакокинетика и Фармакодинамика |
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| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/80 |
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| author | G. V. Mokrov A. M. Likhosherstov V. V. Barchukov V. N. Stolyaruk I. B. Tsorin M. B. Vititnova S. A. Kryzhanovskiy T. A. Gudasheva |
| author_facet | G. V. Mokrov A. M. Likhosherstov V. V. Barchukov V. N. Stolyaruk I. B. Tsorin M. B. Vititnova S. A. Kryzhanovskiy T. A. Gudasheva |
| author_sort | G. V. Mokrov |
| collection | DOAJ |
| description | A new compound ALM-803 (trihydrochloride N1-(3,4,5-trimethoxybenzyl)-N2-{2-[(3,4,5-trimethoxybenzyl)amino]ethyl}-1,2-ethanediamine) was synthesized as analog of ALM 802, differing from it by the position of the methoxy groups in the phenyl rings. It is established that this structural change leads to the disappearance of anti-ischemic activity and antiarrhythmic activity on the model of aconitine arrhythmia in rats, but the antiarrhythmic activity on models of chloride-calcium arrhythmia and electrical fibrillation of the heart of rats remained (1 mg/kg, intravenously). |
| format | Article |
| id | doaj-art-222c9840a8bd4d6193e1440f2299aec4 |
| institution | Kabale University |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2019-01-01 |
| publisher | LLC “Publisher OKI” |
| record_format | Article |
| series | Фармакокинетика и Фармакодинамика |
| spelling | doaj-art-222c9840a8bd4d6193e1440f2299aec42025-08-20T03:57:48ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302019-01-010161110.24411/2587-7836-2019-1003379Study of methoxy-group position influence on compound alm-802 cardiotropic activityG. V. Mokrov0A. M. Likhosherstov1V. V. Barchukov2V. N. Stolyaruk3I. B. Tsorin4M. B. Vititnova5S. A. Kryzhanovskiy6T. A. Gudasheva7FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»A new compound ALM-803 (trihydrochloride N1-(3,4,5-trimethoxybenzyl)-N2-{2-[(3,4,5-trimethoxybenzyl)amino]ethyl}-1,2-ethanediamine) was synthesized as analog of ALM 802, differing from it by the position of the methoxy groups in the phenyl rings. It is established that this structural change leads to the disappearance of anti-ischemic activity and antiarrhythmic activity on the model of aconitine arrhythmia in rats, but the antiarrhythmic activity on models of chloride-calcium arrhythmia and electrical fibrillation of the heart of rats remained (1 mg/kg, intravenously).https://www.pharmacokinetica.ru/jour/article/view/80ингибиторы окисления свободных жирных кислотантиишемическая и антиаритмическая активностилинейные метокси-фенилтриазаалканыалм-802free fatty acid oxidation inhibitorsanti-ischemic and antiarrhythmic activitieslinear methoxyphenyltriazaalkanesalm-802 |
| spellingShingle | G. V. Mokrov A. M. Likhosherstov V. V. Barchukov V. N. Stolyaruk I. B. Tsorin M. B. Vititnova S. A. Kryzhanovskiy T. A. Gudasheva Study of methoxy-group position influence on compound alm-802 cardiotropic activity Фармакокинетика и Фармакодинамика ингибиторы окисления свободных жирных кислот антиишемическая и антиаритмическая активности линейные метокси-фенилтриазаалканы алм-802 free fatty acid oxidation inhibitors anti-ischemic and antiarrhythmic activities linear methoxyphenyltriazaalkanes alm-802 |
| title | Study of methoxy-group position influence on compound alm-802 cardiotropic activity |
| title_full | Study of methoxy-group position influence on compound alm-802 cardiotropic activity |
| title_fullStr | Study of methoxy-group position influence on compound alm-802 cardiotropic activity |
| title_full_unstemmed | Study of methoxy-group position influence on compound alm-802 cardiotropic activity |
| title_short | Study of methoxy-group position influence on compound alm-802 cardiotropic activity |
| title_sort | study of methoxy group position influence on compound alm 802 cardiotropic activity |
| topic | ингибиторы окисления свободных жирных кислот антиишемическая и антиаритмическая активности линейные метокси-фенилтриазаалканы алм-802 free fatty acid oxidation inhibitors anti-ischemic and antiarrhythmic activities linear methoxyphenyltriazaalkanes alm-802 |
| url | https://www.pharmacokinetica.ru/jour/article/view/80 |
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