Colorectal cancer-infiltrating NK cell landscape analysis unravels tissue-resident PD-1+ NK cells in microsatellite instability tumors

Colorectal cancer-infiltrating NK cell landscape analysis unravels tissue-resident PD-1+ NK cells in microsatellite instability tumors

BackgroundNatural killer (NK) cells are innate lymphocytes endowed with potent cytotoxic activity. The presence of tumor-associated NK cells has been correlated with better prognosis in several solid tumors including colorectal cancer (CRC). This malignant disease is the second cause of cancer death...

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Main Authors: Valentina Obino, Chiara Giordano, Simona Carlomagno, Chiara Setti, Marco Greppi, Matteo Bozzo, Silvia Pesce, Elisa Ferretti, Simona Candiani, Letizia Muccio, Enrico Ciferri, Tania Buttiron Webber, Agnese Solari, Fulvia Ortolani, Laura Paleari, Matteo Clavarezza, Andrea Barberis, Marco Filauro, Nicoletta Provinciali, Mariangela Rutigliani, Emanuela Marcenaro, Andrea DeCensi, Mariella Della Chiesa, Simona Sivori
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
human NK cells
colorectal cancer
immune checkpoints
tissue-residency markers
microsatellite status
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1578444/full
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