Epigenetic evolution and clinicopathological implications of distinct DNA methylation profiles in pancreatic ductal adenocarcinoma

Epigenetic evolution and clinicopathological implications of distinct DNA methylation profiles in pancreatic ductal adenocarcinoma

Abstract Pancreatic ductal adenocarcinoma (PDAC) remains a lethal malignancy with poor prognosis. We investigated intratumoral deoxyribonucleic acid methylation heterogeneity by analyzing 44 tumor samples and 5 normal samples from 6 cases of PDAC by using high-resolution methylation arrays. Two dist...

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Bibliographic Details
Main Authors: Keiichiro Kitahama, Yu-Jui Ho, Kaishi Satomi, Takahiro Shibayama, Kiyotaka Nagahama, Kouki Ohtsuka, Hiroaki Ohnishi, Yoshihiro Sakamoto, Junji Shibahara, Akimasa Hayashi
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Pancreatic ductal adenocarcinoma
DNA methylation
Intratumoral heterogeneity
Online Access:https://doi.org/10.1038/s41598-025-13919-y
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