Viral Dynamic Models During COVID‐19: Are We Ready for the Next Pandemic?
ABSTRACT Mathematical models have been used for about 30 years to improve our understanding of virus‐host interaction, in particular during chronic infections. During the COVID‐19 pandemic, these models have been used to provide insights into the natural history of acute SARS‐CoV‐2 infection, optimi...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2025-08-01
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| Series: | CPT: Pharmacometrics & Systems Pharmacology |
| Online Access: | https://doi.org/10.1002/psp4.70055 |
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| author | Aurelien Marc Joshua T. Schiffer France Mentré Alan S. Perelson Jérémie Guedj |
| author_facet | Aurelien Marc Joshua T. Schiffer France Mentré Alan S. Perelson Jérémie Guedj |
| author_sort | Aurelien Marc |
| collection | DOAJ |
| description | ABSTRACT Mathematical models have been used for about 30 years to improve our understanding of virus‐host interaction, in particular during chronic infections. During the COVID‐19 pandemic, these models have been used to provide insights into the natural history of acute SARS‐CoV‐2 infection, optimize antiviral treatment strategies, understand factors associated with transmission, and optimize surveillance systems. The impact of modeling has been accelerated by the availability of unprecedented multidimensional immune data from animal and human systems, which enhanced partnerships between experimentalists and theorists and led to exciting new modeling and statistical developments. In this mini review, we examine the lessons learned from the COVID‐19 pandemic and discuss the main insights provided by mathematical models of viral dynamics at the different stages of the outbreak. Although we focus on respiratory infection, we also consider the new areas for development in anticipation of future acute infections from new or reemerging pathogens. |
| format | Article |
| id | doaj-art-2228ec04307f4cd797c497684bf3dc23 |
| institution | Kabale University |
| issn | 2163-8306 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | CPT: Pharmacometrics & Systems Pharmacology |
| spelling | doaj-art-2228ec04307f4cd797c497684bf3dc232025-08-20T04:02:51ZengWileyCPT: Pharmacometrics & Systems Pharmacology2163-83062025-08-011481289129710.1002/psp4.70055Viral Dynamic Models During COVID‐19: Are We Ready for the Next Pandemic?Aurelien Marc0Joshua T. Schiffer1France Mentré2Alan S. Perelson3Jérémie Guedj4T‐6, Theoretical Biology and Biophysics Los Alamos National Laboratory Los Alamos New Mexico USAVaccine and Infectious Disease Division Fred Hutchinson Cancer Research Center Seattle Washington USAUniversité Paris Cité, IAME INSERM Paris FranceT‐6, Theoretical Biology and Biophysics Los Alamos National Laboratory Los Alamos New Mexico USAUniversité Paris Cité, IAME INSERM Paris FranceABSTRACT Mathematical models have been used for about 30 years to improve our understanding of virus‐host interaction, in particular during chronic infections. During the COVID‐19 pandemic, these models have been used to provide insights into the natural history of acute SARS‐CoV‐2 infection, optimize antiviral treatment strategies, understand factors associated with transmission, and optimize surveillance systems. The impact of modeling has been accelerated by the availability of unprecedented multidimensional immune data from animal and human systems, which enhanced partnerships between experimentalists and theorists and led to exciting new modeling and statistical developments. In this mini review, we examine the lessons learned from the COVID‐19 pandemic and discuss the main insights provided by mathematical models of viral dynamics at the different stages of the outbreak. Although we focus on respiratory infection, we also consider the new areas for development in anticipation of future acute infections from new or reemerging pathogens.https://doi.org/10.1002/psp4.70055 |
| spellingShingle | Aurelien Marc Joshua T. Schiffer France Mentré Alan S. Perelson Jérémie Guedj Viral Dynamic Models During COVID‐19: Are We Ready for the Next Pandemic? CPT: Pharmacometrics & Systems Pharmacology |
| title | Viral Dynamic Models During COVID‐19: Are We Ready for the Next Pandemic? |
| title_full | Viral Dynamic Models During COVID‐19: Are We Ready for the Next Pandemic? |
| title_fullStr | Viral Dynamic Models During COVID‐19: Are We Ready for the Next Pandemic? |
| title_full_unstemmed | Viral Dynamic Models During COVID‐19: Are We Ready for the Next Pandemic? |
| title_short | Viral Dynamic Models During COVID‐19: Are We Ready for the Next Pandemic? |
| title_sort | viral dynamic models during covid 19 are we ready for the next pandemic |
| url | https://doi.org/10.1002/psp4.70055 |
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