Antifungal Activity of Natural Products and their Derivatives Using an Animal Model of Oral Candidiasis: A Systematic Review
Objective: To conduct a systematic review of the literature to elucidate the effectiveness of natural products with antifungal properties in animal infection models, highlighting potential candidates for treating oral candidiasis. Material and Methods: The current study undertook a systematic review...
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| Format: | Article |
| Language: | English |
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Association of Support to Oral Health Research (APESB)
2025-05-01
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| Series: | Pesquisa Brasileira em Odontopediatria e Clínica Integrada |
| Subjects: | |
| Online Access: | https://revista.uepb.edu.br/PBOCI/article/view/4528 |
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| author | Raimundo Euzébio da Costa Neto Ana Karoline Vieira Melo Felipe Queiroga Sarmento Guerra Walicyranison Plinio da Silva-Rocha |
| author_facet | Raimundo Euzébio da Costa Neto Ana Karoline Vieira Melo Felipe Queiroga Sarmento Guerra Walicyranison Plinio da Silva-Rocha |
| author_sort | Raimundo Euzébio da Costa Neto |
| collection | DOAJ |
| description | Objective: To conduct a systematic review of the literature to elucidate the effectiveness of natural products with antifungal properties in animal infection models, highlighting potential candidates for treating oral candidiasis. Material and Methods: The current study undertook a systematic review (registered in the open science framework — DOI10.17605/OSF.IO/8QB5V) using six databases (PubMed, Scopus, Web of Science, Embase, Scholar Google, OpenGrey) focusing on the antifungal potential of natural products and their derivatives, assessed through animal models of oral candidiasis. Results: A total of 22 articles were incorporated for data analysis. Purified compounds were the subject of the most extensive investigations, followed by compounds used in combination, crude and fractionated extracts, and essential oils. These compounds displayed diminished minimum inhibitory concentration (MIC) values and exhibited therapeutic efficacy within the context of the animal model. Conclusion: Among natural and derivative products, ellagic acid associated with 2-hydroxypropyl-β-cyclodextrin, phenethyl ester of caffeic acid, ethyl acetate fraction derived from Eugenia uniflora extract, crude extract of Punica granatum, and nano-encapsulated extract of Erodium glaucophyllum emerge as the most auspicious candidates for the treatment of oral candidiasis. |
| format | Article |
| id | doaj-art-222482c4c92f4e0087a032d250dd0eff |
| institution | DOAJ |
| issn | 1519-0501 1983-4632 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Association of Support to Oral Health Research (APESB) |
| record_format | Article |
| series | Pesquisa Brasileira em Odontopediatria e Clínica Integrada |
| spelling | doaj-art-222482c4c92f4e0087a032d250dd0eff2025-08-20T03:09:28ZengAssociation of Support to Oral Health Research (APESB)Pesquisa Brasileira em Odontopediatria e Clínica Integrada1519-05011983-46322025-05-0125Antifungal Activity of Natural Products and their Derivatives Using an Animal Model of Oral Candidiasis: A Systematic ReviewRaimundo Euzébio da Costa NetoAna Karoline Vieira MeloFelipe Queiroga Sarmento GuerraWalicyranison Plinio da Silva-RochaObjective: To conduct a systematic review of the literature to elucidate the effectiveness of natural products with antifungal properties in animal infection models, highlighting potential candidates for treating oral candidiasis. Material and Methods: The current study undertook a systematic review (registered in the open science framework — DOI10.17605/OSF.IO/8QB5V) using six databases (PubMed, Scopus, Web of Science, Embase, Scholar Google, OpenGrey) focusing on the antifungal potential of natural products and their derivatives, assessed through animal models of oral candidiasis. Results: A total of 22 articles were incorporated for data analysis. Purified compounds were the subject of the most extensive investigations, followed by compounds used in combination, crude and fractionated extracts, and essential oils. These compounds displayed diminished minimum inhibitory concentration (MIC) values and exhibited therapeutic efficacy within the context of the animal model. Conclusion: Among natural and derivative products, ellagic acid associated with 2-hydroxypropyl-β-cyclodextrin, phenethyl ester of caffeic acid, ethyl acetate fraction derived from Eugenia uniflora extract, crude extract of Punica granatum, and nano-encapsulated extract of Erodium glaucophyllum emerge as the most auspicious candidates for the treatment of oral candidiasis.https://revista.uepb.edu.br/PBOCI/article/view/4528Models, AnimalCandida albicansCandidiasis, OralBiological Products |
| spellingShingle | Raimundo Euzébio da Costa Neto Ana Karoline Vieira Melo Felipe Queiroga Sarmento Guerra Walicyranison Plinio da Silva-Rocha Antifungal Activity of Natural Products and their Derivatives Using an Animal Model of Oral Candidiasis: A Systematic Review Pesquisa Brasileira em Odontopediatria e Clínica Integrada Models, Animal Candida albicans Candidiasis, Oral Biological Products |
| title | Antifungal Activity of Natural Products and their Derivatives Using an Animal Model of Oral Candidiasis: A Systematic Review |
| title_full | Antifungal Activity of Natural Products and their Derivatives Using an Animal Model of Oral Candidiasis: A Systematic Review |
| title_fullStr | Antifungal Activity of Natural Products and their Derivatives Using an Animal Model of Oral Candidiasis: A Systematic Review |
| title_full_unstemmed | Antifungal Activity of Natural Products and their Derivatives Using an Animal Model of Oral Candidiasis: A Systematic Review |
| title_short | Antifungal Activity of Natural Products and their Derivatives Using an Animal Model of Oral Candidiasis: A Systematic Review |
| title_sort | antifungal activity of natural products and their derivatives using an animal model of oral candidiasis a systematic review |
| topic | Models, Animal Candida albicans Candidiasis, Oral Biological Products |
| url | https://revista.uepb.edu.br/PBOCI/article/view/4528 |
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