Uridine treatment protects against blood–brain barrier disruption in a rat model of Li-pilocarpine-induced status epilepticus

Uridine treatment protects against blood–brain barrier disruption in a rat model of Li-pilocarpine-induced status epilepticus

IntroductionBlood–brain barrier (BBB) disruption is one of the most striking changes triggered by status epilepticus, which deserves specific attention in terms of novel treatment approaches targeting epileptogenesis. Uridine is a pyrimidine nucleoside with neuroprotective, antiepileptic and antiepi...

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Bibliographic Details
Main Authors: Birnur Aydin, Busra Ocalan Esmerce, Aysen Cakir, Sueda Tuncak, Cansu Koc, Mehmet Cansev, Tulin Alkan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Neuroscience
Subjects:
status epilepticus
uridine
blood–brain barrier
brain edema
aquaporin-4
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2025.1635247/full
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