Creatine-Kinase- and Exercise-Related Muscle Damage Implications for Muscle Performance and Recovery
The appearance of creatine kinase (CK) in blood has been generally considered to be an indirect marker of muscle damage, particularly for diagnosis of medical conditions such as myocardial infarction, muscular dystrophy, and cerebral diseases. However, there is controversy in the literature concerni...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Nutrition and Metabolism |
| Online Access: | http://dx.doi.org/10.1155/2012/960363 |
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| _version_ | 1832559745600323584 |
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| author | Marianne F. Baird Scott M. Graham Julien S. Baker Gordon F. Bickerstaff |
| author_facet | Marianne F. Baird Scott M. Graham Julien S. Baker Gordon F. Bickerstaff |
| author_sort | Marianne F. Baird |
| collection | DOAJ |
| description | The appearance of creatine kinase (CK) in blood has been generally considered to be an indirect marker of muscle damage, particularly for diagnosis of medical conditions such as myocardial infarction, muscular dystrophy, and cerebral diseases. However, there is controversy in the literature concerning its validity in reflecting muscle damage as a consequence of level and intensity of physical exercise. Nonmodifiable factors, for example, ethnicity, age, and gender, can also affect enzyme tissue activity and subsequent CK serum levels. The extent of effect suggests that acceptable upper limits of normal CK levels may need to be reset to recognise the impact of these factors. There is a need for standardisation of protocols and stronger guidelines which would facilitate greater scientific integrity.
The purpose of this paper is to examine current evidence and opinion relating to the release of CK from skeletal muscle in response to physical activity and examine if elevated concentrations are a health concern. |
| format | Article |
| id | doaj-art-2213d43ddf394d6c8af22dec078a7d81 |
| institution | Kabale University |
| issn | 2090-0724 2090-0732 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nutrition and Metabolism |
| spelling | doaj-art-2213d43ddf394d6c8af22dec078a7d812025-02-03T01:29:17ZengWileyJournal of Nutrition and Metabolism2090-07242090-07322012-01-01201210.1155/2012/960363960363Creatine-Kinase- and Exercise-Related Muscle Damage Implications for Muscle Performance and RecoveryMarianne F. Baird0Scott M. Graham1Julien S. Baker2Gordon F. Bickerstaff3School of Science, University of the West of Scotland, Paisley PA1 2BE, UKSchool of Science, University of the West of Scotland, Paisley PA1 2BE, UKSchool of Science, University of the West of Scotland, Paisley PA1 2BE, UKSchool of Science, University of the West of Scotland, Paisley PA1 2BE, UKThe appearance of creatine kinase (CK) in blood has been generally considered to be an indirect marker of muscle damage, particularly for diagnosis of medical conditions such as myocardial infarction, muscular dystrophy, and cerebral diseases. However, there is controversy in the literature concerning its validity in reflecting muscle damage as a consequence of level and intensity of physical exercise. Nonmodifiable factors, for example, ethnicity, age, and gender, can also affect enzyme tissue activity and subsequent CK serum levels. The extent of effect suggests that acceptable upper limits of normal CK levels may need to be reset to recognise the impact of these factors. There is a need for standardisation of protocols and stronger guidelines which would facilitate greater scientific integrity. The purpose of this paper is to examine current evidence and opinion relating to the release of CK from skeletal muscle in response to physical activity and examine if elevated concentrations are a health concern.http://dx.doi.org/10.1155/2012/960363 |
| spellingShingle | Marianne F. Baird Scott M. Graham Julien S. Baker Gordon F. Bickerstaff Creatine-Kinase- and Exercise-Related Muscle Damage Implications for Muscle Performance and Recovery Journal of Nutrition and Metabolism |
| title | Creatine-Kinase- and Exercise-Related Muscle Damage Implications for Muscle Performance and Recovery |
| title_full | Creatine-Kinase- and Exercise-Related Muscle Damage Implications for Muscle Performance and Recovery |
| title_fullStr | Creatine-Kinase- and Exercise-Related Muscle Damage Implications for Muscle Performance and Recovery |
| title_full_unstemmed | Creatine-Kinase- and Exercise-Related Muscle Damage Implications for Muscle Performance and Recovery |
| title_short | Creatine-Kinase- and Exercise-Related Muscle Damage Implications for Muscle Performance and Recovery |
| title_sort | creatine kinase and exercise related muscle damage implications for muscle performance and recovery |
| url | http://dx.doi.org/10.1155/2012/960363 |
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