Therapeutic Effects of PPARα on Neuronal Death and Microvascular Impairment
Peroxisome-proliferator activated receptor-alpha (PPARα) is a broadly expressed nuclear hormone receptor and is a transcription factor for diverse target genes possessing a PPAR response element (PPRE) in the promoter region. The PPRE is highly conserved, and PPARs thus regulate transcription of an...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2015/595426 |
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| author | Elizabeth P. Moran Jian-xing Ma |
| author_facet | Elizabeth P. Moran Jian-xing Ma |
| author_sort | Elizabeth P. Moran |
| collection | DOAJ |
| description | Peroxisome-proliferator activated receptor-alpha (PPARα) is a broadly expressed nuclear hormone receptor and is a transcription factor for diverse target genes possessing a PPAR response element (PPRE) in the promoter region. The PPRE is highly conserved, and PPARs thus regulate transcription of an extensive array of target genes involved in energy metabolism, vascular function, oxidative stress, inflammation, and many other biological processes. PPARα has potent protective effects against neuronal cell death and microvascular impairment, which have been attributed in part to its antioxidant and anti-inflammatory properties. Here we discuss PPARα’s effects in neurodegenerative and microvascular diseases and also recent clinical findings that identified therapeutic effects of a PPARα agonist in diabetic microvascular complications. |
| format | Article |
| id | doaj-art-221374f13e6c4cab982a84df280356ea |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-221374f13e6c4cab982a84df280356ea2025-02-03T01:11:45ZengWileyPPAR Research1687-47571687-47652015-01-01201510.1155/2015/595426595426Therapeutic Effects of PPARα on Neuronal Death and Microvascular ImpairmentElizabeth P. Moran0Jian-xing Ma1Department of Cell Biology, University of Oklahoma Health Sciences Center, 941 Stanton L. Young Boulevard, BSEB 328B, Oklahoma City, OK 73104, USADepartment of Cell Biology, University of Oklahoma Health Sciences Center, 941 Stanton L. Young Boulevard, BSEB 328B, Oklahoma City, OK 73104, USAPeroxisome-proliferator activated receptor-alpha (PPARα) is a broadly expressed nuclear hormone receptor and is a transcription factor for diverse target genes possessing a PPAR response element (PPRE) in the promoter region. The PPRE is highly conserved, and PPARs thus regulate transcription of an extensive array of target genes involved in energy metabolism, vascular function, oxidative stress, inflammation, and many other biological processes. PPARα has potent protective effects against neuronal cell death and microvascular impairment, which have been attributed in part to its antioxidant and anti-inflammatory properties. Here we discuss PPARα’s effects in neurodegenerative and microvascular diseases and also recent clinical findings that identified therapeutic effects of a PPARα agonist in diabetic microvascular complications.http://dx.doi.org/10.1155/2015/595426 |
| spellingShingle | Elizabeth P. Moran Jian-xing Ma Therapeutic Effects of PPARα on Neuronal Death and Microvascular Impairment PPAR Research |
| title | Therapeutic Effects of PPARα on Neuronal Death and Microvascular Impairment |
| title_full | Therapeutic Effects of PPARα on Neuronal Death and Microvascular Impairment |
| title_fullStr | Therapeutic Effects of PPARα on Neuronal Death and Microvascular Impairment |
| title_full_unstemmed | Therapeutic Effects of PPARα on Neuronal Death and Microvascular Impairment |
| title_short | Therapeutic Effects of PPARα on Neuronal Death and Microvascular Impairment |
| title_sort | therapeutic effects of pparα on neuronal death and microvascular impairment |
| url | http://dx.doi.org/10.1155/2015/595426 |
| work_keys_str_mv | AT elizabethpmoran therapeuticeffectsofpparaonneuronaldeathandmicrovascularimpairment AT jianxingma therapeuticeffectsofpparaonneuronaldeathandmicrovascularimpairment |