Viruses in the female lower reproductive tract: a systematic descriptive review of metagenomic investigations
Abstract The lower female reproductive tract (FRT) hosts a complex microbial environment, including eukaryotic and prokaryotic viruses (the virome), whose roles in health and disease are not fully understood. This review consolidates findings on FRT virome composition, revealing the presence of vari...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-11-01
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| Series: | npj Biofilms and Microbiomes |
| Online Access: | https://doi.org/10.1038/s41522-024-00613-6 |
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| author | Layla Honorato Heuder Gustavo Oliveira Paião Antonio Charlys da Costa Tânia Regina Tozetto-Mendoza Maria Cássia Mendes-Correa Steven S. Witkin |
| author_facet | Layla Honorato Heuder Gustavo Oliveira Paião Antonio Charlys da Costa Tânia Regina Tozetto-Mendoza Maria Cássia Mendes-Correa Steven S. Witkin |
| author_sort | Layla Honorato |
| collection | DOAJ |
| description | Abstract The lower female reproductive tract (FRT) hosts a complex microbial environment, including eukaryotic and prokaryotic viruses (the virome), whose roles in health and disease are not fully understood. This review consolidates findings on FRT virome composition, revealing the presence of various viral families and noting significant gaps in knowledge. Understanding interactions between the virome, microbiome, and immune system will provide novel insights for preventing and managing lower genital tract disorders. |
| format | Article |
| id | doaj-art-2212e7ebc7f248a39c120087d62902a5 |
| institution | DOAJ |
| issn | 2055-5008 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Biofilms and Microbiomes |
| spelling | doaj-art-2212e7ebc7f248a39c120087d62902a52025-08-20T02:51:42ZengNature Portfolionpj Biofilms and Microbiomes2055-50082024-11-011011810.1038/s41522-024-00613-6Viruses in the female lower reproductive tract: a systematic descriptive review of metagenomic investigationsLayla Honorato0Heuder Gustavo Oliveira Paião1Antonio Charlys da Costa2Tânia Regina Tozetto-Mendoza3Maria Cássia Mendes-Correa4Steven S. Witkin5Laboratory of Virology (LIM-52), Department of Infectious Diseases and Tropical Medicine, Instituto de Medicina Tropical de São Paulo, Faculdade de Medicina da Universidade de São PauloLaboratory of Virology (LIM-52), Department of Infectious Diseases and Tropical Medicine, Instituto de Medicina Tropical de São Paulo, Faculdade de Medicina da Universidade de São PauloLaboratory of Virology (LIM-52), Department of Infectious Diseases and Tropical Medicine, Instituto de Medicina Tropical de São Paulo, Faculdade de Medicina da Universidade de São PauloLaboratory of Virology (LIM-52), Department of Infectious Diseases and Tropical Medicine, Instituto de Medicina Tropical de São Paulo, Faculdade de Medicina da Universidade de São PauloLaboratory of Virology (LIM-52), Department of Infectious Diseases and Tropical Medicine, Instituto de Medicina Tropical de São Paulo, Faculdade de Medicina da Universidade de São PauloLaboratory of Virology (LIM-52), Department of Infectious Diseases and Tropical Medicine, Instituto de Medicina Tropical de São Paulo, Faculdade de Medicina da Universidade de São PauloAbstract The lower female reproductive tract (FRT) hosts a complex microbial environment, including eukaryotic and prokaryotic viruses (the virome), whose roles in health and disease are not fully understood. This review consolidates findings on FRT virome composition, revealing the presence of various viral families and noting significant gaps in knowledge. Understanding interactions between the virome, microbiome, and immune system will provide novel insights for preventing and managing lower genital tract disorders.https://doi.org/10.1038/s41522-024-00613-6 |
| spellingShingle | Layla Honorato Heuder Gustavo Oliveira Paião Antonio Charlys da Costa Tânia Regina Tozetto-Mendoza Maria Cássia Mendes-Correa Steven S. Witkin Viruses in the female lower reproductive tract: a systematic descriptive review of metagenomic investigations npj Biofilms and Microbiomes |
| title | Viruses in the female lower reproductive tract: a systematic descriptive review of metagenomic investigations |
| title_full | Viruses in the female lower reproductive tract: a systematic descriptive review of metagenomic investigations |
| title_fullStr | Viruses in the female lower reproductive tract: a systematic descriptive review of metagenomic investigations |
| title_full_unstemmed | Viruses in the female lower reproductive tract: a systematic descriptive review of metagenomic investigations |
| title_short | Viruses in the female lower reproductive tract: a systematic descriptive review of metagenomic investigations |
| title_sort | viruses in the female lower reproductive tract a systematic descriptive review of metagenomic investigations |
| url | https://doi.org/10.1038/s41522-024-00613-6 |
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