CRISPR-Cas9-based electrochemical biosensor for the detection of katG gene mutations in isoniazid-resistant tuberculosis

CRISPR-Cas9-based electrochemical biosensor for the detection of katG gene mutations in isoniazid-resistant tuberculosis

Background and purpose: Multidrug-resistant tuberculosis (MDR-TB) remains a significant challenge in tuberculosis (TB) treatment, driven by simultaneous mutations in the rpoB and katG genes that confer resistance to rifampicin and isoniazid. While many molecular diagnostic tools focus on rpoB, the...

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Bibliographic Details
Main Authors: Dika Apriliana Wulandari, Muhammad Ihda Hamlu Liwaissunati Zein, Salma Nur Zakiyyah, Safri Ishmayana, Mehmet Ozsoz, Yeni Wahyuni Hartati, Irkham
Format: Article
Language:English
Published: International Association of Physical Chemists (IAPC) 2025-06-01
Series:ADMET and DMPK
Subjects:
Electrochemistry
guide RNA
ferrocene signal
drug-resistant tuberculosis
Online Access:https://pub.iapchem.org/ojs/index.php/admet/article/view/2766
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