Association of the SOD2 polymorphism (Val6Ala) and SOD activity with vaso-occlusive crisis and acute splenic sequestration in children with sickle cell anemia
The SOD2 polymorphism Val16Ala TàC influences the antioxidative response. This study investigated the association of the SOD2 polymorphism and superoxide dismutase (SOD) activity with vaso-occlusive crisis (VOC) and acute splenic sequestration (ASS) in children with sickle cell anemia (SCA). One hun...
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PAGEPress Publications
2018-02-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | https://www.mjhid.org/index.php/mjhid/article/view/3143 |
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| author | Isabela Cristina Cordeiro Farias Taciana Furtado Mendonça-Belmont Andreia Soares Silva Kleyton Palmeira do Ó Felipe Borba Ferreira Fernanda Silva Medeiros Luydson Richardson Silva Vasconcelos Moacyr Jesus Barreto de Melo Rego Marcos Andre Cavalcanti Bezerra Aderson Silva Araujo Patricia Muniz Mendes Freire Moura Ana Claudia Mendonça Anjos Betânia Lucena Domingues Hatzlhofer Maria do Socorro Mendonça Cavalcanti |
| author_facet | Isabela Cristina Cordeiro Farias Taciana Furtado Mendonça-Belmont Andreia Soares Silva Kleyton Palmeira do Ó Felipe Borba Ferreira Fernanda Silva Medeiros Luydson Richardson Silva Vasconcelos Moacyr Jesus Barreto de Melo Rego Marcos Andre Cavalcanti Bezerra Aderson Silva Araujo Patricia Muniz Mendes Freire Moura Ana Claudia Mendonça Anjos Betânia Lucena Domingues Hatzlhofer Maria do Socorro Mendonça Cavalcanti |
| author_sort | Isabela Cristina Cordeiro Farias |
| collection | DOAJ |
| description | The SOD2 polymorphism Val16Ala TàC influences the antioxidative response. This study investigated the association of the SOD2 polymorphism and superoxide dismutase (SOD) activity with vaso-occlusive crisis (VOC) and acute splenic sequestration (ASS) in children with sickle cell anemia (SCA). One hundred ninety-five children aged 1-9 years old were analyzed. The TC and CC genotypes were associated with lower SOD activity compared with the TT genotype (p=0.0321; p=0.0253, respectively). Furthermore, TC/CC were more frequent in patients with VOC or ASS (p=0.0285; p=0.0090, respectively). These results suggest that the SOD2 polymorphism associated with low SOD activity could be involved in SCA physiopathology. |
| format | Article |
| id | doaj-art-220c2cdedcd54e38b11c63368f113e61 |
| institution | OA Journals |
| issn | 2035-3006 |
| language | English |
| publishDate | 2018-02-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-220c2cdedcd54e38b11c63368f113e612025-08-20T01:47:48ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062018-02-01101e2018012e201801210.4084/mjhid.2018.0121741Association of the SOD2 polymorphism (Val6Ala) and SOD activity with vaso-occlusive crisis and acute splenic sequestration in children with sickle cell anemiaIsabela Cristina Cordeiro Farias0Taciana Furtado Mendonça-BelmontAndreia Soares SilvaKleyton Palmeira do ÓFelipe Borba FerreiraFernanda Silva MedeirosLuydson Richardson Silva VasconcelosMoacyr Jesus Barreto de Melo RegoMarcos Andre Cavalcanti BezerraAderson Silva AraujoPatricia Muniz Mendes Freire MouraAna Claudia Mendonça AnjosBetânia Lucena Domingues HatzlhoferMaria do Socorro Mendonça CavalcantiUniversity of PernambucoThe SOD2 polymorphism Val16Ala TàC influences the antioxidative response. This study investigated the association of the SOD2 polymorphism and superoxide dismutase (SOD) activity with vaso-occlusive crisis (VOC) and acute splenic sequestration (ASS) in children with sickle cell anemia (SCA). One hundred ninety-five children aged 1-9 years old were analyzed. The TC and CC genotypes were associated with lower SOD activity compared with the TT genotype (p=0.0321; p=0.0253, respectively). Furthermore, TC/CC were more frequent in patients with VOC or ASS (p=0.0285; p=0.0090, respectively). These results suggest that the SOD2 polymorphism associated with low SOD activity could be involved in SCA physiopathology.https://www.mjhid.org/index.php/mjhid/article/view/3143Sickle cell anemia, vaso-occlusive crisis, splenic sequestration, SOD2 polymorphism |
| spellingShingle | Isabela Cristina Cordeiro Farias Taciana Furtado Mendonça-Belmont Andreia Soares Silva Kleyton Palmeira do Ó Felipe Borba Ferreira Fernanda Silva Medeiros Luydson Richardson Silva Vasconcelos Moacyr Jesus Barreto de Melo Rego Marcos Andre Cavalcanti Bezerra Aderson Silva Araujo Patricia Muniz Mendes Freire Moura Ana Claudia Mendonça Anjos Betânia Lucena Domingues Hatzlhofer Maria do Socorro Mendonça Cavalcanti Association of the SOD2 polymorphism (Val6Ala) and SOD activity with vaso-occlusive crisis and acute splenic sequestration in children with sickle cell anemia Mediterranean Journal of Hematology and Infectious Diseases Sickle cell anemia, vaso-occlusive crisis, splenic sequestration, SOD2 polymorphism |
| title | Association of the SOD2 polymorphism (Val6Ala) and SOD activity with vaso-occlusive crisis and acute splenic sequestration in children with sickle cell anemia |
| title_full | Association of the SOD2 polymorphism (Val6Ala) and SOD activity with vaso-occlusive crisis and acute splenic sequestration in children with sickle cell anemia |
| title_fullStr | Association of the SOD2 polymorphism (Val6Ala) and SOD activity with vaso-occlusive crisis and acute splenic sequestration in children with sickle cell anemia |
| title_full_unstemmed | Association of the SOD2 polymorphism (Val6Ala) and SOD activity with vaso-occlusive crisis and acute splenic sequestration in children with sickle cell anemia |
| title_short | Association of the SOD2 polymorphism (Val6Ala) and SOD activity with vaso-occlusive crisis and acute splenic sequestration in children with sickle cell anemia |
| title_sort | association of the sod2 polymorphism val6ala and sod activity with vaso occlusive crisis and acute splenic sequestration in children with sickle cell anemia |
| topic | Sickle cell anemia, vaso-occlusive crisis, splenic sequestration, SOD2 polymorphism |
| url | https://www.mjhid.org/index.php/mjhid/article/view/3143 |
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