Association of the SOD2 polymorphism (Val6Ala) and SOD activity with vaso-occlusive crisis and acute splenic sequestration in children with sickle cell anemia

Association of the SOD2 polymorphism (Val6Ala) and SOD activity with vaso-occlusive crisis and acute splenic sequestration in children with sickle cell anemia

The SOD2 polymorphism Val16Ala TàC influences the antioxidative response. This study investigated the association of the SOD2 polymorphism and superoxide dismutase (SOD) activity with vaso-occlusive crisis (VOC) and acute splenic sequestration (ASS) in children with sickle cell anemia (SCA). One hun...

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Main Authors: Isabela Cristina Cordeiro Farias, Taciana Furtado Mendonça-Belmont, Andreia Soares Silva, Kleyton Palmeira do Ó, Felipe Borba Ferreira, Fernanda Silva Medeiros, Luydson Richardson Silva Vasconcelos, Moacyr Jesus Barreto de Melo Rego, Marcos Andre Cavalcanti Bezerra, Aderson Silva Araujo, Patricia Muniz Mendes Freire Moura, Ana Claudia Mendonça Anjos, Betânia Lucena Domingues Hatzlhofer, Maria do Socorro Mendonça Cavalcanti
Format: Article
Language:English
Published: PAGEPress Publications 2018-02-01
Series:Mediterranean Journal of Hematology and Infectious Diseases
Subjects:
Sickle cell anemia, vaso-occlusive crisis, splenic sequestration, SOD2 polymorphism
Online Access:https://www.mjhid.org/index.php/mjhid/article/view/3143
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Summary:The SOD2 polymorphism Val16Ala TàC influences the antioxidative response. This study investigated the association of the SOD2 polymorphism and superoxide dismutase (SOD) activity with vaso-occlusive crisis (VOC) and acute splenic sequestration (ASS) in children with sickle cell anemia (SCA). One hundred ninety-five children aged 1-9 years old were analyzed. The TC and CC genotypes were associated with lower SOD activity compared with the TT genotype (p=0.0321; p=0.0253, respectively). Furthermore, TC/CC were more frequent in patients with VOC or ASS (p=0.0285; p=0.0090, respectively). These results suggest that the SOD2 polymorphism associated with low SOD activity could be involved in SCA physiopathology.
ISSN:2035-3006

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