The role of Fusobacterium nucleatum in macrophage M2 polarization and NF-κB pathway activation in colorectal cancer

The role of Fusobacterium nucleatum in macrophage M2 polarization and NF-κB pathway activation in colorectal cancer

Fusobacterium nucleatum is strongly linked to colorectal cancer (CRC) progression, but its mechanisms for influencing macrophage polarization and tumor development are not well understood. We established an in vitro model of F. nucleatum infection in RAW264.7 macrophages to investigate these process...

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Bibliographic Details
Main Authors: Wei Zheng, Yuxin Wang, Haoyang Sun, Surina Bao, Shuai Ge, Chunshan Quan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
Fusobacterium nucleatum
colorectal cancer
macrophage polarization
NF-κB signaling pathway
trascriptome
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1549564/full
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