PD-L1 knockout or ZG16 overexpression inhibits PDAC progression and modulates TAM polarization

PD-L1 knockout or ZG16 overexpression inhibits PDAC progression and modulates TAM polarization

CRISPR/Cas9-mediated genome editing has the potential to delete PD-L1 both on the cell surface and inside the cell, thereby inhibiting tumor growth and migration and overcoming immunosuppression. ZG16, with its lectin structure, can reduce PD-L1 expression on the cell surface. However, direct compar...

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Bibliographic Details
Main Authors: Hui Meng, Manman Nan, Yizhen Li, Yi Ding, Xiaokun Fang, Weiqian Ma, Mingzhi Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
PD-L1 knockout
ZG16 intervention
CRISPR/Cas9
PDAC progression
TAM polarization
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1510179/full
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