Feasibility and Safety of Food Containing Acanthopanax senticosus for Treating Patients with Cancer-Related Fatigue
Background: Cancer-related fatigue (CRF) is a major obstacle to quality of life. Acanthopanax senticosus Harms (ASH) is available as a botanical adaptogen food worldwide. Objective: This study aimed to assess the feasibility and safety of ASH in patients with CRF. Methods: Fifteen patients with CRF...
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| Format: | Article |
| Language: | English |
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Mary Ann Liebert
2024-10-01
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| Series: | Palliative Medicine Reports |
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| Online Access: | https://www.liebertpub.com/doi/10.1089/pmr.2024.0041 |
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| author | Yutaka Kawano Nanae Watanabe Masahiko Nishiyama Tousei Ohmura Hiroyoshi Mihara Kaoru Ono Maki Tanaka Yasushi Sato Tetsu Tomonari Hidekatsu Takeda Tetsuji Takayama |
| author_facet | Yutaka Kawano Nanae Watanabe Masahiko Nishiyama Tousei Ohmura Hiroyoshi Mihara Kaoru Ono Maki Tanaka Yasushi Sato Tetsu Tomonari Hidekatsu Takeda Tetsuji Takayama |
| author_sort | Yutaka Kawano |
| collection | DOAJ |
| description | Background: Cancer-related fatigue (CRF) is a major obstacle to quality of life. Acanthopanax senticosus Harms (ASH) is available as a botanical adaptogen food worldwide. Objective: This study aimed to assess the feasibility and safety of ASH in patients with CRF. Methods: Fifteen patients with CRF consumed ASH drink for 28 days. The primary endpoint was the completion rate of the study, and the secondary endpoints were changes in brief fatigue inventory (BFI), oxidative stress markers, and adverse events. Results: Seven patients successfully completed the study. Four patients who had BFI <5.5 at enrollment revealed a decrease in BFI. The biological antioxidant potential/diacron-reactive oxygen metabolites ratio, potential antioxidant capacity, was increased but not significant (p = 0.063). No adverse events attributable to ASH were observed. Conclusions: Approximately 50% patients were successful in consuming ASH for 28 days. Patients with mild CRF showed improvement by using ASH. However, further investigations are needed to validate these findings. |
| format | Article |
| id | doaj-art-22077c2c210340b0b8ca0c4123c69aa4 |
| institution | Kabale University |
| issn | 2689-2820 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Mary Ann Liebert |
| record_format | Article |
| series | Palliative Medicine Reports |
| spelling | doaj-art-22077c2c210340b0b8ca0c4123c69aa42025-08-20T03:49:37ZengMary Ann LiebertPalliative Medicine Reports2689-28202024-10-015138138610.1089/pmr.2024.0041Feasibility and Safety of Food Containing Acanthopanax senticosus for Treating Patients with Cancer-Related FatigueYutaka Kawano0Nanae Watanabe1Masahiko Nishiyama2Tousei Ohmura3Hiroyoshi Mihara4Kaoru Ono5Maki Tanaka6Yasushi Sato7Tetsu Tomonari8Hidekatsu Takeda9Tetsuji Takayama10Department of Community Medicine and Medical Science, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.Higashi Sapporo Hospital, Sapporo, Japan.Higashi Sapporo Hospital, Sapporo, Japan.Higashi Sapporo Hospital, Sapporo, Japan.Higashi Sapporo Hospital, Sapporo, Japan.Higashi Sapporo Hospital, Sapporo, Japan.Department of Clinical Laboratory Science, School of Medical Technology, Health Sciences University of Hokkaido, Sapporo, Japan.Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.Department of Physical Therapy, Sapporo Medical University School of Medicine, Sapporo, Japan.Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.Background: Cancer-related fatigue (CRF) is a major obstacle to quality of life. Acanthopanax senticosus Harms (ASH) is available as a botanical adaptogen food worldwide. Objective: This study aimed to assess the feasibility and safety of ASH in patients with CRF. Methods: Fifteen patients with CRF consumed ASH drink for 28 days. The primary endpoint was the completion rate of the study, and the secondary endpoints were changes in brief fatigue inventory (BFI), oxidative stress markers, and adverse events. Results: Seven patients successfully completed the study. Four patients who had BFI <5.5 at enrollment revealed a decrease in BFI. The biological antioxidant potential/diacron-reactive oxygen metabolites ratio, potential antioxidant capacity, was increased but not significant (p = 0.063). No adverse events attributable to ASH were observed. Conclusions: Approximately 50% patients were successful in consuming ASH for 28 days. Patients with mild CRF showed improvement by using ASH. However, further investigations are needed to validate these findings.https://www.liebertpub.com/doi/10.1089/pmr.2024.0041Acanthopanax senticosus Harmscancer-related fatiguequality of lifeadaptogen |
| spellingShingle | Yutaka Kawano Nanae Watanabe Masahiko Nishiyama Tousei Ohmura Hiroyoshi Mihara Kaoru Ono Maki Tanaka Yasushi Sato Tetsu Tomonari Hidekatsu Takeda Tetsuji Takayama Feasibility and Safety of Food Containing Acanthopanax senticosus for Treating Patients with Cancer-Related Fatigue Palliative Medicine Reports Acanthopanax senticosus Harms cancer-related fatigue quality of life adaptogen |
| title | Feasibility and Safety of Food Containing Acanthopanax senticosus for Treating Patients with Cancer-Related Fatigue |
| title_full | Feasibility and Safety of Food Containing Acanthopanax senticosus for Treating Patients with Cancer-Related Fatigue |
| title_fullStr | Feasibility and Safety of Food Containing Acanthopanax senticosus for Treating Patients with Cancer-Related Fatigue |
| title_full_unstemmed | Feasibility and Safety of Food Containing Acanthopanax senticosus for Treating Patients with Cancer-Related Fatigue |
| title_short | Feasibility and Safety of Food Containing Acanthopanax senticosus for Treating Patients with Cancer-Related Fatigue |
| title_sort | feasibility and safety of food containing acanthopanax senticosus for treating patients with cancer related fatigue |
| topic | Acanthopanax senticosus Harms cancer-related fatigue quality of life adaptogen |
| url | https://www.liebertpub.com/doi/10.1089/pmr.2024.0041 |
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