Changes of plasma arginase I levels in hemodialysis patients with coronary heart disease
Objective To determine the correlation between the arginase I(Arg I) level and coronary heart disease(CHD) in hemodialysis(HD) patients.Methods Forty-five HD patients and 45 healthy volunteers were chosen from May 2011 to Apr.2014 in the First Affiliated Hospital of Hebei North University.HD patient...
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Editorial Department of Journal of Clinical Nephrology
2015-01-01
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| Series: | Linchuang shenzangbing zazhi |
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| author | WEN Hong-mei YANG Lei REN Xiao-li SUN Yi-bing YAN Min-na |
| author_facet | WEN Hong-mei YANG Lei REN Xiao-li SUN Yi-bing YAN Min-na |
| author_sort | WEN Hong-mei |
| collection | DOAJ |
| description | Objective To determine the correlation between the arginase I(Arg I) level and coronary heart disease(CHD) in hemodialysis(HD) patients.Methods Forty-five HD patients and 45 healthy volunteers were chosen from May 2011 to Apr.2014 in the First Affiliated Hospital of Hebei North University.HD patients were sub-divided into CHD subgroup and non-CHD sub-group.Plasma Arg I,IL-6 and TNF-a were measured by ELISA kits.Results There was no statistically significant difference in gender and age between HD patients and healthy controls(P>0.05).There was no obvious difference in Arg I level between HD patients and healthy controls(12.97 ± 7.32 vs.9.63 ± 4.65 ng/ml,P>0.05).Arg I level in HD patients with CHD was higher than HD patients without CHD(19.72 ± 10.54 vs.10.01 ± 7.73 ng/ml,P<0.05),and higher than healthy controls(9.63 ± 4.65 ng/ml,P<0.05).IL-6 and TNF-a levels were increased in HD patients as compared with healthy controls(IL-6:28.66 ± 10.13 vs.4.17 ± 2.42 pg/rnl,P<0.05,TNF-a:51.39 ± 6.53 vs.15.22 ± 2.1 pg/ml,P<0.05),but showed no significant difference between HD patients with or without CHD(IL-6:25.62 ± 7.27 vs.29.45 + 11.36 pg/ml;TNF-α:33.57 ± 6.72 vs.37.69 ± 7.57pg/ml).IL-6 and TNF-a levels had no significant correlation with Arg I level in HD patients.Conclusions Arg Ⅰ levels may be associated with the occurrence of CHD in HD patients. |
| format | Article |
| id | doaj-art-22000421ebe24d5d8f6bceb0954e263a |
| institution | Kabale University |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2015-01-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-22000421ebe24d5d8f6bceb0954e263a2025-08-20T03:52:51ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902015-01-0148548857920798Changes of plasma arginase I levels in hemodialysis patients with coronary heart diseaseWEN Hong-meiYANG LeiREN Xiao-liSUN Yi-bingYAN Min-naObjective To determine the correlation between the arginase I(Arg I) level and coronary heart disease(CHD) in hemodialysis(HD) patients.Methods Forty-five HD patients and 45 healthy volunteers were chosen from May 2011 to Apr.2014 in the First Affiliated Hospital of Hebei North University.HD patients were sub-divided into CHD subgroup and non-CHD sub-group.Plasma Arg I,IL-6 and TNF-a were measured by ELISA kits.Results There was no statistically significant difference in gender and age between HD patients and healthy controls(P>0.05).There was no obvious difference in Arg I level between HD patients and healthy controls(12.97 ± 7.32 vs.9.63 ± 4.65 ng/ml,P>0.05).Arg I level in HD patients with CHD was higher than HD patients without CHD(19.72 ± 10.54 vs.10.01 ± 7.73 ng/ml,P<0.05),and higher than healthy controls(9.63 ± 4.65 ng/ml,P<0.05).IL-6 and TNF-a levels were increased in HD patients as compared with healthy controls(IL-6:28.66 ± 10.13 vs.4.17 ± 2.42 pg/rnl,P<0.05,TNF-a:51.39 ± 6.53 vs.15.22 ± 2.1 pg/ml,P<0.05),but showed no significant difference between HD patients with or without CHD(IL-6:25.62 ± 7.27 vs.29.45 + 11.36 pg/ml;TNF-α:33.57 ± 6.72 vs.37.69 ± 7.57pg/ml).IL-6 and TNF-a levels had no significant correlation with Arg I level in HD patients.Conclusions Arg Ⅰ levels may be associated with the occurrence of CHD in HD patients.http://www.lcszb.com/thesisDetails?columnId=57920798&Fpath=home&index=0HemodialysisCoronary heart diseaseArginase ⅠInterleukin-6Tumor necrosis factor-a |
| spellingShingle | WEN Hong-mei YANG Lei REN Xiao-li SUN Yi-bing YAN Min-na Changes of plasma arginase I levels in hemodialysis patients with coronary heart disease Linchuang shenzangbing zazhi Hemodialysis Coronary heart disease Arginase Ⅰ Interleukin-6 Tumor necrosis factor-a |
| title | Changes of plasma arginase I levels in hemodialysis patients with coronary heart disease |
| title_full | Changes of plasma arginase I levels in hemodialysis patients with coronary heart disease |
| title_fullStr | Changes of plasma arginase I levels in hemodialysis patients with coronary heart disease |
| title_full_unstemmed | Changes of plasma arginase I levels in hemodialysis patients with coronary heart disease |
| title_short | Changes of plasma arginase I levels in hemodialysis patients with coronary heart disease |
| title_sort | changes of plasma arginase i levels in hemodialysis patients with coronary heart disease |
| topic | Hemodialysis Coronary heart disease Arginase Ⅰ Interleukin-6 Tumor necrosis factor-a |
| url | http://www.lcszb.com/thesisDetails?columnId=57920798&Fpath=home&index=0 |
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