Changes of plasma arginase I levels in hemodialysis patients with coronary heart disease
Objective To determine the correlation between the arginase I(Arg I) level and coronary heart disease(CHD) in hemodialysis(HD) patients.Methods Forty-five HD patients and 45 healthy volunteers were chosen from May 2011 to Apr.2014 in the First Affiliated Hospital of Hebei North University.HD patient...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2015-01-01
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| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57920798&Fpath=home&index=0 |
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| Summary: | Objective To determine the correlation between the arginase I(Arg I) level and coronary heart disease(CHD) in hemodialysis(HD) patients.Methods Forty-five HD patients and 45 healthy volunteers were chosen from May 2011 to Apr.2014 in the First Affiliated Hospital of Hebei North University.HD patients were sub-divided into CHD subgroup and non-CHD sub-group.Plasma Arg I,IL-6 and TNF-a were measured by ELISA kits.Results There was no statistically significant difference in gender and age between HD patients and healthy controls(P>0.05).There was no obvious difference in Arg I level between HD patients and healthy controls(12.97 ± 7.32 vs.9.63 ± 4.65 ng/ml,P>0.05).Arg I level in HD patients with CHD was higher than HD patients without CHD(19.72 ± 10.54 vs.10.01 ± 7.73 ng/ml,P<0.05),and higher than healthy controls(9.63 ± 4.65 ng/ml,P<0.05).IL-6 and TNF-a levels were increased in HD patients as compared with healthy controls(IL-6:28.66 ± 10.13 vs.4.17 ± 2.42 pg/rnl,P<0.05,TNF-a:51.39 ± 6.53 vs.15.22 ± 2.1 pg/ml,P<0.05),but showed no significant difference between HD patients with or without CHD(IL-6:25.62 ± 7.27 vs.29.45 + 11.36 pg/ml;TNF-α:33.57 ± 6.72 vs.37.69 ± 7.57pg/ml).IL-6 and TNF-a levels had no significant correlation with Arg I level in HD patients.Conclusions Arg Ⅰ levels may be associated with the occurrence of CHD in HD patients. |
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| ISSN: | 1671-2390 |