Gellan gum and polyvinylpyrrolidone (PVP) as binding agents in extrusion/spheronization pellet formulations
The aim of this work was to evaluate gellan gum as binder in pellet formulations, with theophylline as the model drug, in comparison with polyvinylpyrrolidone (PVP). A full 32 factorial design was realized, with binder and diluent factors at three levels each. Pellets were produced by the extrusion/...
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| Format: | Article |
| Language: | English |
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Sciendo
2019-03-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2019-0007 |
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| author | Barbosa Eduardo José Ferraz Humberto Gomes |
| author_facet | Barbosa Eduardo José Ferraz Humberto Gomes |
| author_sort | Barbosa Eduardo José |
| collection | DOAJ |
| description | The aim of this work was to evaluate gellan gum as binder in pellet formulations, with theophylline as the model drug, in comparison with polyvinylpyrrolidone (PVP). A full 32 factorial design was realized, with binder and diluent factors at three levels each. Pellets were produced by the extrusion/spheronization technique, and dried in a fluid-ized bed. Physical tests and dissolution tests were conducted. The results showed that the binder factor was not significant for pellet size and granulometry distribution. Rather, trends of a different response of gellan gum were identified, in comparison with PVP, in aspect ratio and dissolution tests: more round pellets were obtained in formulations with gellan gum, and more variable dissolution resulted when this polysaccharide was present. Therefore, if the usage of this compound in immediate release pellet formulations is verified, this justifies the interest in the development of sustained release systems using gellan gum. |
| format | Article |
| id | doaj-art-21faccd6f4604360bc4482386e0d3623 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2019-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-21faccd6f4604360bc4482386e0d36232025-02-02T17:01:54ZengSciendoActa Pharmaceutica1846-95582019-03-016919910910.2478/acph-2019-0007acph-2019-0007Gellan gum and polyvinylpyrrolidone (PVP) as binding agents in extrusion/spheronization pellet formulationsBarbosa Eduardo José0Ferraz Humberto Gomes1Department of Pharmacy, Faculty of Pharmaceutical SciencesUniversity of São Paulo, São PauloBrazilDepartment of Pharmacy, Faculty of Pharmaceutical SciencesUniversity of São Paulo, São PauloBrazilThe aim of this work was to evaluate gellan gum as binder in pellet formulations, with theophylline as the model drug, in comparison with polyvinylpyrrolidone (PVP). A full 32 factorial design was realized, with binder and diluent factors at three levels each. Pellets were produced by the extrusion/spheronization technique, and dried in a fluid-ized bed. Physical tests and dissolution tests were conducted. The results showed that the binder factor was not significant for pellet size and granulometry distribution. Rather, trends of a different response of gellan gum were identified, in comparison with PVP, in aspect ratio and dissolution tests: more round pellets were obtained in formulations with gellan gum, and more variable dissolution resulted when this polysaccharide was present. Therefore, if the usage of this compound in immediate release pellet formulations is verified, this justifies the interest in the development of sustained release systems using gellan gum.https://doi.org/10.2478/acph-2019-0007gellan gumpolyvinylpyrrolidonepelletsextrusionspheronization |
| spellingShingle | Barbosa Eduardo José Ferraz Humberto Gomes Gellan gum and polyvinylpyrrolidone (PVP) as binding agents in extrusion/spheronization pellet formulations Acta Pharmaceutica gellan gum polyvinylpyrrolidone pellets extrusion spheronization |
| title | Gellan gum and polyvinylpyrrolidone (PVP) as binding agents in extrusion/spheronization pellet formulations |
| title_full | Gellan gum and polyvinylpyrrolidone (PVP) as binding agents in extrusion/spheronization pellet formulations |
| title_fullStr | Gellan gum and polyvinylpyrrolidone (PVP) as binding agents in extrusion/spheronization pellet formulations |
| title_full_unstemmed | Gellan gum and polyvinylpyrrolidone (PVP) as binding agents in extrusion/spheronization pellet formulations |
| title_short | Gellan gum and polyvinylpyrrolidone (PVP) as binding agents in extrusion/spheronization pellet formulations |
| title_sort | gellan gum and polyvinylpyrrolidone pvp as binding agents in extrusion spheronization pellet formulations |
| topic | gellan gum polyvinylpyrrolidone pellets extrusion spheronization |
| url | https://doi.org/10.2478/acph-2019-0007 |
| work_keys_str_mv | AT barbosaeduardojose gellangumandpolyvinylpyrrolidonepvpasbindingagentsinextrusionspheronizationpelletformulations AT ferrazhumbertogomes gellangumandpolyvinylpyrrolidonepvpasbindingagentsinextrusionspheronizationpelletformulations |