Thermo mammogram as a tool to assess response to neoadjuvant chemotherapy in breast carcinoma
Introduction: Response to neoadjuvant chemotherapy (NACT) is predicted by clinical examination alone in locally advanced breast carcinoma. This study uses thermo mammogram (TMG) to assess the response. Aim and Objectives: The aim is to study TMG changes during NACT in breast cancer and predict respo...
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2019-01-01
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| Series: | Indian Journal of Medical and Paediatric Oncology |
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| Online Access: | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2019;volume=40;issue=5;spage=25;epage=32;aulast=Shanmugam |
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| author | Subbiah Shanmugam Gopu Govindasamy Sujay Susikar Muniasamy Palaniyandi |
| author_facet | Subbiah Shanmugam Gopu Govindasamy Sujay Susikar Muniasamy Palaniyandi |
| author_sort | Subbiah Shanmugam |
| collection | DOAJ |
| description | Introduction: Response to neoadjuvant chemotherapy (NACT) is predicted by clinical examination alone in locally advanced breast carcinoma. This study uses thermo mammogram (TMG) to assess the response. Aim and Objectives: The aim is to study TMG changes during NACT in breast cancer and predict response to NACT in locally advanced carcinoma and to compare clinical response with TMG response/changes in any form. Patients and Methods: All patients with locally advanced breast cancer who had treated with NACT were included in this study. Baseline TMG picture was taken using illumina360° (digital robotic rotational thermography device for 360 degree view of each breast) system before chemotherapy. TMG was repeated before next cycle. All patients were also assessed clinically during and after each cycle of chemotherapy. To assess the potential of TMG in predicting tissue response to chemotherapy, the precool, postcool, and the temperature difference between precool and postcool before every cycle were analyzed. Results: A total of 19 patients were analyzed. Eight patients had complete clinical response, six patients had partial response, and five patients had static disease. Median of precool, temperature difference between precool and postcool for patients between no response and complete response did not show statistically significant difference. However, the median of postcool spot temperature showed statistically significant difference. Median of postcool temperature difference for patients between partial response and complete response showed statistically significant difference. The median of postcool spot temperature for patients with no response and partial response did not show statistically significant difference. Precool temperature difference for all the visits showed no statistically significant difference. Conclusion: This preliminary study suggests that the TMG has potential for monitoring NACT response in breast cancer patients. Postcool temperature measurement is an early indicator of response to NACT. |
| format | Article |
| id | doaj-art-21f33b40c2cd4f73a1a7c5f693886102 |
| institution | Kabale University |
| issn | 0971-5851 0975-2129 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-21f33b40c2cd4f73a1a7c5f6938861022025-08-20T03:54:42ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58510975-21292019-01-01405253210.4103/ijmpo.ijmpo_144_17Thermo mammogram as a tool to assess response to neoadjuvant chemotherapy in breast carcinomaSubbiah ShanmugamGopu GovindasamySujay SusikarMuniasamy PalaniyandiIntroduction: Response to neoadjuvant chemotherapy (NACT) is predicted by clinical examination alone in locally advanced breast carcinoma. This study uses thermo mammogram (TMG) to assess the response. Aim and Objectives: The aim is to study TMG changes during NACT in breast cancer and predict response to NACT in locally advanced carcinoma and to compare clinical response with TMG response/changes in any form. Patients and Methods: All patients with locally advanced breast cancer who had treated with NACT were included in this study. Baseline TMG picture was taken using illumina360° (digital robotic rotational thermography device for 360 degree view of each breast) system before chemotherapy. TMG was repeated before next cycle. All patients were also assessed clinically during and after each cycle of chemotherapy. To assess the potential of TMG in predicting tissue response to chemotherapy, the precool, postcool, and the temperature difference between precool and postcool before every cycle were analyzed. Results: A total of 19 patients were analyzed. Eight patients had complete clinical response, six patients had partial response, and five patients had static disease. Median of precool, temperature difference between precool and postcool for patients between no response and complete response did not show statistically significant difference. However, the median of postcool spot temperature showed statistically significant difference. Median of postcool temperature difference for patients between partial response and complete response showed statistically significant difference. The median of postcool spot temperature for patients with no response and partial response did not show statistically significant difference. Precool temperature difference for all the visits showed no statistically significant difference. Conclusion: This preliminary study suggests that the TMG has potential for monitoring NACT response in breast cancer patients. Postcool temperature measurement is an early indicator of response to NACT.http://www.ijmpo.org/article.asp?issn=0971-5851;year=2019;volume=40;issue=5;spage=25;epage=32;aulast=ShanmugamAssessment of responsebreast carcinomathermo mammogram |
| spellingShingle | Subbiah Shanmugam Gopu Govindasamy Sujay Susikar Muniasamy Palaniyandi Thermo mammogram as a tool to assess response to neoadjuvant chemotherapy in breast carcinoma Indian Journal of Medical and Paediatric Oncology Assessment of response breast carcinoma thermo mammogram |
| title | Thermo mammogram as a tool to assess response to neoadjuvant chemotherapy in breast carcinoma |
| title_full | Thermo mammogram as a tool to assess response to neoadjuvant chemotherapy in breast carcinoma |
| title_fullStr | Thermo mammogram as a tool to assess response to neoadjuvant chemotherapy in breast carcinoma |
| title_full_unstemmed | Thermo mammogram as a tool to assess response to neoadjuvant chemotherapy in breast carcinoma |
| title_short | Thermo mammogram as a tool to assess response to neoadjuvant chemotherapy in breast carcinoma |
| title_sort | thermo mammogram as a tool to assess response to neoadjuvant chemotherapy in breast carcinoma |
| topic | Assessment of response breast carcinoma thermo mammogram |
| url | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2019;volume=40;issue=5;spage=25;epage=32;aulast=Shanmugam |
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