Efficacy and safety of peripheral magnetic stimulation for the treatment of intractable hiccups after stroke: a prospective, blinded, parallel randomized controlled clinical trial
AimsPreclinical studies indicate that magnetic stimulation may be an efficacious treatment for intractable hiccups in post-stroke patients. This study aimed to investigate repetitive peripheral magnetic stimulation (rPMS) potential efficacy and safety for treating intractable hiccups.MethodsThis ran...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1615318/full |
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| author | Qiliang Liu Qiliang Liu Yijia Jiang Jingbo Sun Huiyu Liu Huiyu Liu Junbin Chen Chenze Jiao Daiyi Chen Zicai Liu |
| author_facet | Qiliang Liu Qiliang Liu Yijia Jiang Jingbo Sun Huiyu Liu Huiyu Liu Junbin Chen Chenze Jiao Daiyi Chen Zicai Liu |
| author_sort | Qiliang Liu |
| collection | DOAJ |
| description | AimsPreclinical studies indicate that magnetic stimulation may be an efficacious treatment for intractable hiccups in post-stroke patients. This study aimed to investigate repetitive peripheral magnetic stimulation (rPMS) potential efficacy and safety for treating intractable hiccups.MethodsThis randomized controlled trial randomly assigned 60 patients with stroke with intractable hiccups to receive rPMS (n = 30) or metoclopramide (n = 30). The control group received a 10 mg metoclopramide injection intramuscularly twice daily, while the experimental group underwent daily repeated magnetic stimulation at 5 Hz with 1,200 stimuli using a round coil transversally positioned below the xiphoid process. Metoclopramide or rPMS was administered until the hiccups were entirely ceased. The efficacy of the two groups was evaluated after 1 week of treatment.ResultsAll 60 enrolled male patients completed the study. The proportion of patients achieving complete cure was significantly higher in the magnetic stimulation group than in the metoclopramide group (23/30 vs. 15/30; p = 0.032). However, total response rate (cure + improvement) did not differ significantly between groups (29/30 vs. 28/30; p = 1.000). No significant differences were observed in recurrence rates (p = 0.052). Just one case of fatigue and one case of dizziness were observed in the metoclopramide group.ConclusionMagnetic stimulation may be superior to metoclopramide in achieving complete cure of intractable hiccups after stroke, though both treatments show high overall response rates.Clinical trial registrationhttps://www.chictr.org.cn/, ChiCTR2200060435. |
| format | Article |
| id | doaj-art-21eedcb668db44c4ad2f4d0813d4e4bc |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-21eedcb668db44c4ad2f4d0813d4e4bc2025-08-20T03:36:13ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-08-011610.3389/fneur.2025.16153181615318Efficacy and safety of peripheral magnetic stimulation for the treatment of intractable hiccups after stroke: a prospective, blinded, parallel randomized controlled clinical trialQiliang Liu0Qiliang Liu1Yijia Jiang2Jingbo Sun3Huiyu Liu4Huiyu Liu5Junbin Chen6Chenze Jiao7Daiyi Chen8Zicai Liu9Guangzhou University of Traditional Chinese Medicine, Guangzhou, ChinaYue Bei People’s Hospital, Shaoguan, ChinaDepartment of Rehabilitation Medicine, Foresea Life Insurance Shaoguan Hospital, Shaoguan, ChinaGuangzhou University of Traditional Chinese Medicine, Guangzhou, ChinaYue Bei People’s Hospital, Shaoguan, ChinaDepartment of Rehabilitation Medicine, Foresea Life Insurance Shaoguan Hospital, Shaoguan, ChinaYue Bei People’s Hospital, Shaoguan, ChinaYue Bei People’s Hospital, Shaoguan, ChinaGuangzhou University of Traditional Chinese Medicine, Guangzhou, ChinaDepartment of Rehabilitation Medicine, Shaoguan First People’s Hospital, Shaoguan, ChinaAimsPreclinical studies indicate that magnetic stimulation may be an efficacious treatment for intractable hiccups in post-stroke patients. This study aimed to investigate repetitive peripheral magnetic stimulation (rPMS) potential efficacy and safety for treating intractable hiccups.MethodsThis randomized controlled trial randomly assigned 60 patients with stroke with intractable hiccups to receive rPMS (n = 30) or metoclopramide (n = 30). The control group received a 10 mg metoclopramide injection intramuscularly twice daily, while the experimental group underwent daily repeated magnetic stimulation at 5 Hz with 1,200 stimuli using a round coil transversally positioned below the xiphoid process. Metoclopramide or rPMS was administered until the hiccups were entirely ceased. The efficacy of the two groups was evaluated after 1 week of treatment.ResultsAll 60 enrolled male patients completed the study. The proportion of patients achieving complete cure was significantly higher in the magnetic stimulation group than in the metoclopramide group (23/30 vs. 15/30; p = 0.032). However, total response rate (cure + improvement) did not differ significantly between groups (29/30 vs. 28/30; p = 1.000). No significant differences were observed in recurrence rates (p = 0.052). Just one case of fatigue and one case of dizziness were observed in the metoclopramide group.ConclusionMagnetic stimulation may be superior to metoclopramide in achieving complete cure of intractable hiccups after stroke, though both treatments show high overall response rates.Clinical trial registrationhttps://www.chictr.org.cn/, ChiCTR2200060435.https://www.frontiersin.org/articles/10.3389/fneur.2025.1615318/fullmagnetic stimulationintractable hiccupsstrokeRCTrTMS |
| spellingShingle | Qiliang Liu Qiliang Liu Yijia Jiang Jingbo Sun Huiyu Liu Huiyu Liu Junbin Chen Chenze Jiao Daiyi Chen Zicai Liu Efficacy and safety of peripheral magnetic stimulation for the treatment of intractable hiccups after stroke: a prospective, blinded, parallel randomized controlled clinical trial Frontiers in Neurology magnetic stimulation intractable hiccups stroke RCT rTMS |
| title | Efficacy and safety of peripheral magnetic stimulation for the treatment of intractable hiccups after stroke: a prospective, blinded, parallel randomized controlled clinical trial |
| title_full | Efficacy and safety of peripheral magnetic stimulation for the treatment of intractable hiccups after stroke: a prospective, blinded, parallel randomized controlled clinical trial |
| title_fullStr | Efficacy and safety of peripheral magnetic stimulation for the treatment of intractable hiccups after stroke: a prospective, blinded, parallel randomized controlled clinical trial |
| title_full_unstemmed | Efficacy and safety of peripheral magnetic stimulation for the treatment of intractable hiccups after stroke: a prospective, blinded, parallel randomized controlled clinical trial |
| title_short | Efficacy and safety of peripheral magnetic stimulation for the treatment of intractable hiccups after stroke: a prospective, blinded, parallel randomized controlled clinical trial |
| title_sort | efficacy and safety of peripheral magnetic stimulation for the treatment of intractable hiccups after stroke a prospective blinded parallel randomized controlled clinical trial |
| topic | magnetic stimulation intractable hiccups stroke RCT rTMS |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1615318/full |
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