Comparison of Serenoa repens, lycopene, and selenium versus dutasteride for the treatment of LUTS/BPH: an Italian multicenter case-control prospective study (COMP study)

Comparison of Serenoa repens, lycopene, and selenium versus dutasteride for the treatment of LUTS/BPH: an Italian multicenter case-control prospective study (COMP study)

IntroductionHistorically, medical therapy of BPH has had its foundations in alpha-blockers in monotherapy or in combination with 5 alpha reductase inhibitors (5-ARIs); in particular, two important trials (COMBAT and MTOPS) have demonstrated the pivotal role of combination therapy instead of monother...

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Main Authors: Giuseppe Morgia, Arturo Lo Giudice, Sebastiano Cimino, Giulio Reale, Gaetano Larganà, Enza La Manna, Massimo Madonia, Alessandro Tedde, Francesco Santaniello, Giuseppe Vespasiani, Stefano Zaganelli, Salvatore Arnone, Nicola Cruciano, Maurizio Carrino, Francesco Persico, Carlo Terrone, Rafaela Malinaric, Andrea Minervini, Marco Carini, Giorgio Ivan Russo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Urology
Subjects:
BPH
Serenoa repens
luts
prostate
5ARI
Online Access:https://www.frontiersin.org/articles/10.3389/fruro.2025.1565240/full
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