Hypoxic-Ischemic Neonatal Encephalopathy: Animal Experiments for Neuroprotective Therapies
Hypoxic-ischemic neonatal encephalopathy and ensuing brain damage is still an important problem in modern perinatal medicine. In this paper, we would like to share some of the results of our recent studies on neuroprotective therapies in animal experiments, as well as some literature reviews. From t...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Stroke Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2013/659374 |
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| _version_ | 1849307701973090304 |
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| author | Hiroshi Sameshima Tsuyomu Ikenoue |
| author_facet | Hiroshi Sameshima Tsuyomu Ikenoue |
| author_sort | Hiroshi Sameshima |
| collection | DOAJ |
| description | Hypoxic-ischemic neonatal encephalopathy and ensuing brain damage is still an important problem in modern perinatal medicine. In this paper, we would like to share some of the results of our recent studies on neuroprotective therapies in animal experiments, as well as some literature reviews. From the basic animal studies, we have now obtained some possible candidates for therapeutic measures against hypoxic-ischemic neonatal encephalopathy. For example, they are hypothermia, rehabilitation, free radical scavenger, neurotrophic factors and growth factors, steroid, calcium channel blocker, vagal stimulation, some anti apoptotic agents, pre- and post conditioning, antioxidants, cell therapy with stem cells, modulators of K(+)-ATP channels, and so on. Whether combination of these therapies may be more beneficial than any single therapy needs to be clarified. Hypoxia-ischemia is a complicated condition, in which the cause, severity, and time-course are different in each case. Likewise, each fetus has its own inherent potentials such as adaptation, preconditioning-tolerance, and intolerance. Therefore, further extensive studies are required to establish an individualized strategy for neuroprotection against perinatal hypoxic-ischemic insult. |
| format | Article |
| id | doaj-art-21e39ec8ab7e45beb31b20bbe79e57b7 |
| institution | Kabale University |
| issn | 2090-8105 2042-0056 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stroke Research and Treatment |
| spelling | doaj-art-21e39ec8ab7e45beb31b20bbe79e57b72025-08-20T03:54:42ZengWileyStroke Research and Treatment2090-81052042-00562013-01-01201310.1155/2013/659374659374Hypoxic-Ischemic Neonatal Encephalopathy: Animal Experiments for Neuroprotective TherapiesHiroshi Sameshima0Tsuyomu Ikenoue1Department of Obstetrics and Gynecology and Center for Perinatal Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kiyotake, Kihara, Miyazaki 889-1692, JapanDepartment of Obstetrics and Gynecology and Center for Perinatal Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kiyotake, Kihara, Miyazaki 889-1692, JapanHypoxic-ischemic neonatal encephalopathy and ensuing brain damage is still an important problem in modern perinatal medicine. In this paper, we would like to share some of the results of our recent studies on neuroprotective therapies in animal experiments, as well as some literature reviews. From the basic animal studies, we have now obtained some possible candidates for therapeutic measures against hypoxic-ischemic neonatal encephalopathy. For example, they are hypothermia, rehabilitation, free radical scavenger, neurotrophic factors and growth factors, steroid, calcium channel blocker, vagal stimulation, some anti apoptotic agents, pre- and post conditioning, antioxidants, cell therapy with stem cells, modulators of K(+)-ATP channels, and so on. Whether combination of these therapies may be more beneficial than any single therapy needs to be clarified. Hypoxia-ischemia is a complicated condition, in which the cause, severity, and time-course are different in each case. Likewise, each fetus has its own inherent potentials such as adaptation, preconditioning-tolerance, and intolerance. Therefore, further extensive studies are required to establish an individualized strategy for neuroprotection against perinatal hypoxic-ischemic insult.http://dx.doi.org/10.1155/2013/659374 |
| spellingShingle | Hiroshi Sameshima Tsuyomu Ikenoue Hypoxic-Ischemic Neonatal Encephalopathy: Animal Experiments for Neuroprotective Therapies Stroke Research and Treatment |
| title | Hypoxic-Ischemic Neonatal Encephalopathy: Animal Experiments for Neuroprotective Therapies |
| title_full | Hypoxic-Ischemic Neonatal Encephalopathy: Animal Experiments for Neuroprotective Therapies |
| title_fullStr | Hypoxic-Ischemic Neonatal Encephalopathy: Animal Experiments for Neuroprotective Therapies |
| title_full_unstemmed | Hypoxic-Ischemic Neonatal Encephalopathy: Animal Experiments for Neuroprotective Therapies |
| title_short | Hypoxic-Ischemic Neonatal Encephalopathy: Animal Experiments for Neuroprotective Therapies |
| title_sort | hypoxic ischemic neonatal encephalopathy animal experiments for neuroprotective therapies |
| url | http://dx.doi.org/10.1155/2013/659374 |
| work_keys_str_mv | AT hiroshisameshima hypoxicischemicneonatalencephalopathyanimalexperimentsforneuroprotectivetherapies AT tsuyomuikenoue hypoxicischemicneonatalencephalopathyanimalexperimentsforneuroprotectivetherapies |