The protective effect and mechanism of (-)-(S)-B-973B on SH-SY5Y cell injury induced by 1-me-thyl-4-phenyl pyridine

The protective effect and mechanism of (-)-(S)-B-973B on SH-SY5Y cell injury induced by 1-me-thyl-4-phenyl pyridine

Objective To investigate the protective effect and mechanism of (-)-(S)-B-973B, an allosteric modulator of α7 nicotinic acetylcholine receptor, on SH-SY5Y cell injury induced by 1-methyl-4-phenyl pyridine (MPP+). Methods CCK-8 assay was used to investigate the effect of 0, 100, 200, 300, 500, 1 000,...

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Bibliographic Details
Main Author: LI Huanhuan, QIAO Zhen, WANG Ji, CAO Xiu, DU Xixun
Format: Article
Language:zho
Published: Editorial Office of Journal of Precision Medicine 2025-06-01
Series:精准医学杂志
Subjects:
parkinson disease|alpha7 nicotinic acetylcholine receptor|cell line|tumor|membrane potential|mitochondrial|oxidative stress|apoptosis
Online Access:https://jpmed.qdu.edu.cn/fileup/2096-529X/PDF/1750385719659-1875839888.pdf
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