Body‐Wide Inactivation of the Myc‐Like Mlx Transcription Factor Network Accelerates Aging and Increases the Lifetime Cancer Incidence

Body‐Wide Inactivation of the Myc‐Like Mlx Transcription Factor Network Accelerates Aging and Increases the Lifetime Cancer Incidence

Abstract The “Mlx” and “Myc” transcription factor networks cross‐communicate and share many common gene targets. Myc's activity depends upon its heterodimerization with Max, whereas the Mlx Network requires that the Max‐like factor Mlx associate with the Myc‐like factors MondoA or ChREBP. The c...

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Bibliographic Details
Main Authors: Huabo Wang, Taylor Stevens, Jie Lu, Alexander Roberts, Clinton Van't Land, Radhika Muzumdar, Zhenwei Gong, Jerry Vockley, Edward V. Prochownik
Format: Article
Language:English
Published: Wiley 2024-09-01
Series:Advanced Science
Subjects:
glycolysis
mitochondria
reactive oxygen species
TCA cycle
telomeres
Warburg effect
Online Access:https://doi.org/10.1002/advs.202401593
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