Drug-Induced Hematological Cytopenia in Kidney Transplantation and the Challenges It Poses for Kidney Transplant Physicians
Drug-induced hematological cytopenia is common in kidney transplantation. Various cytopenia including leucopenia (neutropenia), thrombocytopenia, and anemia can occur in kidney transplant recipients. Persistent severe leucopenia or neutropenia can lead to opportunistic infections of various etiologi...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2018/9429265 |
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| author | Muhammad Abdul Mabood Khalil Muhammad Ashhad Ullah Khalil Taqi F. Taufeeq Khan Jackson Tan |
| author_facet | Muhammad Abdul Mabood Khalil Muhammad Ashhad Ullah Khalil Taqi F. Taufeeq Khan Jackson Tan |
| author_sort | Muhammad Abdul Mabood Khalil |
| collection | DOAJ |
| description | Drug-induced hematological cytopenia is common in kidney transplantation. Various cytopenia including leucopenia (neutropenia), thrombocytopenia, and anemia can occur in kidney transplant recipients. Persistent severe leucopenia or neutropenia can lead to opportunistic infections of various etiologies. On the contrary, reducing or stopping immunosuppressive medications in these events can provoke a rejection. Transplant clinicians are often faced with the delicate dilemma of balancing cytopenia and rejection from adjustments of immunosuppressive regimen. Differentials of drug-induced cytopenia are wide. Identification of culprit medication and subsequent modification is also challenging. In this review, we will discuss individual drug implicated in causing cytopenia and correlate it with corresponding literature evidence. |
| format | Article |
| id | doaj-art-21d1abac5524487cb44607fa396bbe31 |
| institution | Kabale University |
| issn | 2090-0007 2090-0015 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Transplantation |
| spelling | doaj-art-21d1abac5524487cb44607fa396bbe312025-02-03T01:24:18ZengWileyJournal of Transplantation2090-00072090-00152018-01-01201810.1155/2018/94292659429265Drug-Induced Hematological Cytopenia in Kidney Transplantation and the Challenges It Poses for Kidney Transplant PhysiciansMuhammad Abdul Mabood Khalil0Muhammad Ashhad Ullah Khalil1Taqi F. Taufeeq Khan2Jackson Tan3RIPAS Hospital, Bandar Seri Begawan BA1710, Brunei DarussalamInstitute of Kidney Diseases, Hayatabad, Peshawar 25000, KPK, PakistanKing Salman Armed Forces Hospital, Tabuk King Abdul Aziz Rd., Tabuk 47512, Saudi ArabiaRIPAS Hospital, Bandar Seri Begawan BA1710, Brunei DarussalamDrug-induced hematological cytopenia is common in kidney transplantation. Various cytopenia including leucopenia (neutropenia), thrombocytopenia, and anemia can occur in kidney transplant recipients. Persistent severe leucopenia or neutropenia can lead to opportunistic infections of various etiologies. On the contrary, reducing or stopping immunosuppressive medications in these events can provoke a rejection. Transplant clinicians are often faced with the delicate dilemma of balancing cytopenia and rejection from adjustments of immunosuppressive regimen. Differentials of drug-induced cytopenia are wide. Identification of culprit medication and subsequent modification is also challenging. In this review, we will discuss individual drug implicated in causing cytopenia and correlate it with corresponding literature evidence.http://dx.doi.org/10.1155/2018/9429265 |
| spellingShingle | Muhammad Abdul Mabood Khalil Muhammad Ashhad Ullah Khalil Taqi F. Taufeeq Khan Jackson Tan Drug-Induced Hematological Cytopenia in Kidney Transplantation and the Challenges It Poses for Kidney Transplant Physicians Journal of Transplantation |
| title | Drug-Induced Hematological Cytopenia in Kidney Transplantation and the Challenges It Poses for Kidney Transplant Physicians |
| title_full | Drug-Induced Hematological Cytopenia in Kidney Transplantation and the Challenges It Poses for Kidney Transplant Physicians |
| title_fullStr | Drug-Induced Hematological Cytopenia in Kidney Transplantation and the Challenges It Poses for Kidney Transplant Physicians |
| title_full_unstemmed | Drug-Induced Hematological Cytopenia in Kidney Transplantation and the Challenges It Poses for Kidney Transplant Physicians |
| title_short | Drug-Induced Hematological Cytopenia in Kidney Transplantation and the Challenges It Poses for Kidney Transplant Physicians |
| title_sort | drug induced hematological cytopenia in kidney transplantation and the challenges it poses for kidney transplant physicians |
| url | http://dx.doi.org/10.1155/2018/9429265 |
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