Serum uric acid as a biomarker for metabolic dysfunction-associated steatotic liver disease: insights from ultrasound elastography in a Chinese cohort
Abstract Background To evaluate the association between serum uric acid (SUA) levels and metabolic dysfunction-associated steatotic liver disease (MASLD), defined as excessive fat accumulation in the liver accompanied by at least one cardiometabolic risk factor, reflecting metabolic abnormalities as...
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BMC
2025-02-01
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| Online Access: | https://doi.org/10.1186/s12876-025-03666-9 |
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| author | Zhe Chang Zhe Liu |
| author_facet | Zhe Chang Zhe Liu |
| author_sort | Zhe Chang |
| collection | DOAJ |
| description | Abstract Background To evaluate the association between serum uric acid (SUA) levels and metabolic dysfunction-associated steatotic liver disease (MASLD), defined as excessive fat accumulation in the liver accompanied by at least one cardiometabolic risk factor, reflecting metabolic abnormalities associated with the condition, in a Chinese adult population. Methods This study included 3829 participants aged ≥ 18 years who underwent abdominal transient elastography and had complete SUA data. SUA was categorized into low, medium, and high tertiles. Hepatic steatosis was defined as a controlled attenuation parameter (CAP) ≥ 248 dB/m. MASLD diagnosis followed the latest definitions by relevant liver disease associations. Logistic regression analyzed the association between SUA and MASLD. Restricted cubic spline regression assessed non-linear relationships. Results A total of 1737 participants were diagnosed with MASLD. SUA levels were higher in the MASLD group (5.79 ± 1.50 mg/dL) than in the non-MASLD group (5.03 ± 1.35 mg/dL). SUA was linearly related to MASLD (P for nonlinearity = 0.8451). Both medium and high SUA groups had increased MASLD risk compared to the low SUA group (P < 0.05). Each unit increase in SUA was associated with a 14% higher risk of MASLD (odds ratio [OR] = 1.14, P = 0.0004). Conclusions This study highlights the association between SUA levels and MASLD, suggesting that SUA may serve as a potential biomarker for MASLD risk assessment. Monitoring SUA levels could inform preventive strategies and facilitate early intervention, contributing to improved MASLD management. |
| format | Article |
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| language | English |
| publishDate | 2025-02-01 |
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| series | BMC Gastroenterology |
| spelling | doaj-art-21c9f362b6a54a699fc790340ebdbbf92025-08-20T02:15:11ZengBMCBMC Gastroenterology1471-230X2025-02-0125111110.1186/s12876-025-03666-9Serum uric acid as a biomarker for metabolic dysfunction-associated steatotic liver disease: insights from ultrasound elastography in a Chinese cohortZhe Chang0Zhe Liu1Department of Ultrasound Medicine, Xi’an Fengcheng HospitalDepartment of Ultrasound Medicine, Xi’an Fengcheng HospitalAbstract Background To evaluate the association between serum uric acid (SUA) levels and metabolic dysfunction-associated steatotic liver disease (MASLD), defined as excessive fat accumulation in the liver accompanied by at least one cardiometabolic risk factor, reflecting metabolic abnormalities associated with the condition, in a Chinese adult population. Methods This study included 3829 participants aged ≥ 18 years who underwent abdominal transient elastography and had complete SUA data. SUA was categorized into low, medium, and high tertiles. Hepatic steatosis was defined as a controlled attenuation parameter (CAP) ≥ 248 dB/m. MASLD diagnosis followed the latest definitions by relevant liver disease associations. Logistic regression analyzed the association between SUA and MASLD. Restricted cubic spline regression assessed non-linear relationships. Results A total of 1737 participants were diagnosed with MASLD. SUA levels were higher in the MASLD group (5.79 ± 1.50 mg/dL) than in the non-MASLD group (5.03 ± 1.35 mg/dL). SUA was linearly related to MASLD (P for nonlinearity = 0.8451). Both medium and high SUA groups had increased MASLD risk compared to the low SUA group (P < 0.05). Each unit increase in SUA was associated with a 14% higher risk of MASLD (odds ratio [OR] = 1.14, P = 0.0004). Conclusions This study highlights the association between SUA levels and MASLD, suggesting that SUA may serve as a potential biomarker for MASLD risk assessment. Monitoring SUA levels could inform preventive strategies and facilitate early intervention, contributing to improved MASLD management.https://doi.org/10.1186/s12876-025-03666-9Serum uric acidUltrasound elastographyControlled attenuation parameterLiverMASLD |
| spellingShingle | Zhe Chang Zhe Liu Serum uric acid as a biomarker for metabolic dysfunction-associated steatotic liver disease: insights from ultrasound elastography in a Chinese cohort BMC Gastroenterology Serum uric acid Ultrasound elastography Controlled attenuation parameter Liver MASLD |
| title | Serum uric acid as a biomarker for metabolic dysfunction-associated steatotic liver disease: insights from ultrasound elastography in a Chinese cohort |
| title_full | Serum uric acid as a biomarker for metabolic dysfunction-associated steatotic liver disease: insights from ultrasound elastography in a Chinese cohort |
| title_fullStr | Serum uric acid as a biomarker for metabolic dysfunction-associated steatotic liver disease: insights from ultrasound elastography in a Chinese cohort |
| title_full_unstemmed | Serum uric acid as a biomarker for metabolic dysfunction-associated steatotic liver disease: insights from ultrasound elastography in a Chinese cohort |
| title_short | Serum uric acid as a biomarker for metabolic dysfunction-associated steatotic liver disease: insights from ultrasound elastography in a Chinese cohort |
| title_sort | serum uric acid as a biomarker for metabolic dysfunction associated steatotic liver disease insights from ultrasound elastography in a chinese cohort |
| topic | Serum uric acid Ultrasound elastography Controlled attenuation parameter Liver MASLD |
| url | https://doi.org/10.1186/s12876-025-03666-9 |
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