re-expression inhibits growth and enhances radiosensitivity in nasopharyngeal carcinoma
Although radiation therapy is the primary treatment for nasopharyngeal carcinoma, radioresistance remains a major obstacle to successful treatment in many cases, and the exact underlying molecular mechanisms are still ill-defined. EMP2 , epithelial membrane protein-2, was a recently identified poten...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-03-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317695972 |
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| _version_ | 1850093303910891520 |
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| author | Mei Tang Ru-yan Liu Cong Zhou Meng-zhen Yuan Dong-ming Wu Zhu Yuan Peng Zhang Jin-yi Lang |
| author_facet | Mei Tang Ru-yan Liu Cong Zhou Meng-zhen Yuan Dong-ming Wu Zhu Yuan Peng Zhang Jin-yi Lang |
| author_sort | Mei Tang |
| collection | DOAJ |
| description | Although radiation therapy is the primary treatment for nasopharyngeal carcinoma, radioresistance remains a major obstacle to successful treatment in many cases, and the exact underlying molecular mechanisms are still ill-defined. EMP2 , epithelial membrane protein-2, was a recently identified potential oncogene involved in multiple biological processes including cell migration and cell proliferation. This study was to explore the potential relationship between EMP2 expression, nasopharyngeal carcinoma genesis, and radioresistance. EMP2 expression status in 98 nasopharyngeal carcinoma clinical samples was examined by immunohistochemical staining. As a result, most of the nasopharyngeal carcinoma tumor samples were weakly or negatively stained, while paired adjacent normal tissues were moderately or strongly stained. Moreover, patients with higher expression of EMP2 had significant longer survival times. EMP2 re-expression suppresses cell growth, induces S-phase cell cycle arrest, and promotes radiosensitivity and apoptosis in nasopharyngeal carcinoma cells. These results support that loss of EMP2 is common, and its re-expression may serve as an approach to enhance radiation sensitivity in nasopharyngeal carcinoma. |
| format | Article |
| id | doaj-art-21c8f447e4d44cf8a7c8b1c3c2afb929 |
| institution | DOAJ |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-21c8f447e4d44cf8a7c8b1c3c2afb9292025-08-20T02:41:57ZengSAGE PublishingTumor Biology1423-03802017-03-013910.1177/1010428317695972re-expression inhibits growth and enhances radiosensitivity in nasopharyngeal carcinomaMei Tang0Ru-yan Liu1Cong Zhou2Meng-zhen Yuan3Dong-ming Wu4Zhu Yuan5Peng Zhang6Jin-yi Lang7Laboratory of Tumor Biotherapy, Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, ChinaDepartment of oncology, FuLing Central Hospital, Chongqing, ChinaLaboratory of Tumor Biotherapy, Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, ChinaDepartment of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, ChinaLaboratory of Tumor Biotherapy, Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, ChinaLaboratory of Tumor Biotherapy, Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, ChinaDepartment of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, ChinaDepartment of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, ChinaAlthough radiation therapy is the primary treatment for nasopharyngeal carcinoma, radioresistance remains a major obstacle to successful treatment in many cases, and the exact underlying molecular mechanisms are still ill-defined. EMP2 , epithelial membrane protein-2, was a recently identified potential oncogene involved in multiple biological processes including cell migration and cell proliferation. This study was to explore the potential relationship between EMP2 expression, nasopharyngeal carcinoma genesis, and radioresistance. EMP2 expression status in 98 nasopharyngeal carcinoma clinical samples was examined by immunohistochemical staining. As a result, most of the nasopharyngeal carcinoma tumor samples were weakly or negatively stained, while paired adjacent normal tissues were moderately or strongly stained. Moreover, patients with higher expression of EMP2 had significant longer survival times. EMP2 re-expression suppresses cell growth, induces S-phase cell cycle arrest, and promotes radiosensitivity and apoptosis in nasopharyngeal carcinoma cells. These results support that loss of EMP2 is common, and its re-expression may serve as an approach to enhance radiation sensitivity in nasopharyngeal carcinoma.https://doi.org/10.1177/1010428317695972 |
| spellingShingle | Mei Tang Ru-yan Liu Cong Zhou Meng-zhen Yuan Dong-ming Wu Zhu Yuan Peng Zhang Jin-yi Lang re-expression inhibits growth and enhances radiosensitivity in nasopharyngeal carcinoma Tumor Biology |
| title | re-expression inhibits growth and enhances radiosensitivity in nasopharyngeal carcinoma |
| title_full | re-expression inhibits growth and enhances radiosensitivity in nasopharyngeal carcinoma |
| title_fullStr | re-expression inhibits growth and enhances radiosensitivity in nasopharyngeal carcinoma |
| title_full_unstemmed | re-expression inhibits growth and enhances radiosensitivity in nasopharyngeal carcinoma |
| title_short | re-expression inhibits growth and enhances radiosensitivity in nasopharyngeal carcinoma |
| title_sort | re expression inhibits growth and enhances radiosensitivity in nasopharyngeal carcinoma |
| url | https://doi.org/10.1177/1010428317695972 |
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