NLRP3 Inflammasome-Mediated Osteoarthritis: The Role of Epigenetics
The prevalence of osteoarthritis (OA) notably surges with age and weight gain. The most common clinical therapeutic drugs are painkillers, yet they cannot impede the deteriorating course of OA. Thus, understanding OA’s pathogenesis and devising effective therapies is crucial. It is generally recogni...
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| Format: | Article |
| Language: | English |
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2025-01-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/14/1/71 |
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| author | Yuzhou Liu Ying Wang Ping Yan Ning Cui Kejin Xu Da Liu Yuan Tian Lingling Cao |
| author_facet | Yuzhou Liu Ying Wang Ping Yan Ning Cui Kejin Xu Da Liu Yuan Tian Lingling Cao |
| author_sort | Yuzhou Liu |
| collection | DOAJ |
| description | The prevalence of osteoarthritis (OA) notably surges with age and weight gain. The most common clinical therapeutic drugs are painkillers, yet they cannot impede the deteriorating course of OA. Thus, understanding OA’s pathogenesis and devising effective therapies is crucial. It is generally recognized that inflammation, <i>pyroptosis</i>, and OA progression are tightly linked. The activation of NLRP3 inflammasome can lead to the discharge of the pro-inflammatory cytokines Interleukin-1β and IL-18, intensifying subsequent inflammatory reactions and promoting OA development. Conversely, the imbalance caused by deacetylase-regulated NLRP3 inflammasome underlies the chronic mild inflammation related to degenerative diseases. Therefore, this article expounds on the mechanism of OA pathogenesis and the role of histone deacetylases (HDACs) in NLRP3 inflammasome-triggered OA, and illustrates the application of HDAC inhibitors in OA, striving to provide more insights into novel OA treatment approaches. |
| format | Article |
| id | doaj-art-21c44d322e954e6c9b798547e635f8f2 |
| institution | Kabale University |
| issn | 2079-7737 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj-art-21c44d322e954e6c9b798547e635f8f22025-01-24T13:23:31ZengMDPI AGBiology2079-77372025-01-011417110.3390/biology14010071NLRP3 Inflammasome-Mediated Osteoarthritis: The Role of EpigeneticsYuzhou Liu0Ying Wang1Ping Yan2Ning Cui3Kejin Xu4Da Liu5Yuan Tian6Lingling Cao7School of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, ChinaSchool of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, ChinaCollege of Traditional Chinese Medicine, Changchun University of Traditional Chinese Medicine, Changchun 130117, ChinaCollege of Traditional Chinese Medicine, Changchun University of Traditional Chinese Medicine, Changchun 130117, ChinaSchool of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, ChinaPublic Laboratory Centre, Changchun University of Chinese Medicine, Changchun 130117, ChinaClinical School of Medicine, Changchun University of Traditional Chinese Medicine, Changchun 130117, ChinaClinical School of Medicine, Changchun University of Traditional Chinese Medicine, Changchun 130117, ChinaThe prevalence of osteoarthritis (OA) notably surges with age and weight gain. The most common clinical therapeutic drugs are painkillers, yet they cannot impede the deteriorating course of OA. Thus, understanding OA’s pathogenesis and devising effective therapies is crucial. It is generally recognized that inflammation, <i>pyroptosis</i>, and OA progression are tightly linked. The activation of NLRP3 inflammasome can lead to the discharge of the pro-inflammatory cytokines Interleukin-1β and IL-18, intensifying subsequent inflammatory reactions and promoting OA development. Conversely, the imbalance caused by deacetylase-regulated NLRP3 inflammasome underlies the chronic mild inflammation related to degenerative diseases. Therefore, this article expounds on the mechanism of OA pathogenesis and the role of histone deacetylases (HDACs) in NLRP3 inflammasome-triggered OA, and illustrates the application of HDAC inhibitors in OA, striving to provide more insights into novel OA treatment approaches.https://www.mdpi.com/2079-7737/14/1/71HDACsNLRP3 inflammasomeHDAC inhibitorsosteoarthritischondrocyte pyroptosis |
| spellingShingle | Yuzhou Liu Ying Wang Ping Yan Ning Cui Kejin Xu Da Liu Yuan Tian Lingling Cao NLRP3 Inflammasome-Mediated Osteoarthritis: The Role of Epigenetics Biology HDACs NLRP3 inflammasome HDAC inhibitors osteoarthritis chondrocyte pyroptosis |
| title | NLRP3 Inflammasome-Mediated Osteoarthritis: The Role of Epigenetics |
| title_full | NLRP3 Inflammasome-Mediated Osteoarthritis: The Role of Epigenetics |
| title_fullStr | NLRP3 Inflammasome-Mediated Osteoarthritis: The Role of Epigenetics |
| title_full_unstemmed | NLRP3 Inflammasome-Mediated Osteoarthritis: The Role of Epigenetics |
| title_short | NLRP3 Inflammasome-Mediated Osteoarthritis: The Role of Epigenetics |
| title_sort | nlrp3 inflammasome mediated osteoarthritis the role of epigenetics |
| topic | HDACs NLRP3 inflammasome HDAC inhibitors osteoarthritis chondrocyte pyroptosis |
| url | https://www.mdpi.com/2079-7737/14/1/71 |
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