SARS-CoV-2 drug resistance and therapeutic approaches
In light of the transition of COVID-19 from a pandemic to an endemic phase, there is still a dire need to address challenges associated with drug resistance, particularly among immunocompromised and high-risk populations. This review explores the current state of research on SARS-CoV-2 drug resistan...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025003603 |
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| author | Sania Batool Santosh Chokkakula Ju Hwan Jeong Yun Hee Baek Min-Suk Song |
| author_facet | Sania Batool Santosh Chokkakula Ju Hwan Jeong Yun Hee Baek Min-Suk Song |
| author_sort | Sania Batool |
| collection | DOAJ |
| description | In light of the transition of COVID-19 from a pandemic to an endemic phase, there is still a dire need to address challenges associated with drug resistance, particularly among immunocompromised and high-risk populations. This review explores the current state of research on SARS-CoV-2 drug resistance and underscores the ongoing need for effective therapeutic strategies. It critically evaluates existing knowledge on resistance mechanisms and therapeutic options, aiming to consolidate information and highlight areas for future research. By examining the complex interactions between the virus and its host, the review advocates for a multifaceted approach, including combination therapies, targeted drug development, and continuous surveillance of viral mutations. It also emphasizes the impact of evolving viral variants on antiviral efficacy and suggests adaptive treatment protocols. This review aims to enhance our understanding of SARS-CoV-2 drug resistance and contribute to more effective management of COVID-19 through a discussion of promising strategies such as drug repurposing and combination therapies. |
| format | Article |
| id | doaj-art-21c01d0709d24fcd91da9a9dcb5478f0 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-21c01d0709d24fcd91da9a9dcb5478f02025-02-02T05:28:42ZengElsevierHeliyon2405-84402025-01-01112e41980SARS-CoV-2 drug resistance and therapeutic approachesSania Batool0Santosh Chokkakula1Ju Hwan Jeong2Yun Hee Baek3Min-Suk Song4Department of Microbiology, Chungbuk National University, College of Medicine and Medical Research Institute, Cheongju 28644, Chungbuk, Republic of KoreaDepartment of Microbiology, Chungbuk National University, College of Medicine and Medical Research Institute, Cheongju 28644, Chungbuk, Republic of KoreaDepartment of Microbiology, Chungbuk National University, College of Medicine and Medical Research Institute, Cheongju 28644, Chungbuk, Republic of KoreaDepartment of Microbiology, Chungbuk National University, College of Medicine and Medical Research Institute, Cheongju 28644, Chungbuk, Republic of KoreaCorresponding author.; Department of Microbiology, Chungbuk National University, College of Medicine and Medical Research Institute, Cheongju 28644, Chungbuk, Republic of KoreaIn light of the transition of COVID-19 from a pandemic to an endemic phase, there is still a dire need to address challenges associated with drug resistance, particularly among immunocompromised and high-risk populations. This review explores the current state of research on SARS-CoV-2 drug resistance and underscores the ongoing need for effective therapeutic strategies. It critically evaluates existing knowledge on resistance mechanisms and therapeutic options, aiming to consolidate information and highlight areas for future research. By examining the complex interactions between the virus and its host, the review advocates for a multifaceted approach, including combination therapies, targeted drug development, and continuous surveillance of viral mutations. It also emphasizes the impact of evolving viral variants on antiviral efficacy and suggests adaptive treatment protocols. This review aims to enhance our understanding of SARS-CoV-2 drug resistance and contribute to more effective management of COVID-19 through a discussion of promising strategies such as drug repurposing and combination therapies.http://www.sciencedirect.com/science/article/pii/S2405844025003603Antiviral drugsSARS-CoV-2Drug resistanceResistance mechanismTherapeutic strategies |
| spellingShingle | Sania Batool Santosh Chokkakula Ju Hwan Jeong Yun Hee Baek Min-Suk Song SARS-CoV-2 drug resistance and therapeutic approaches Heliyon Antiviral drugs SARS-CoV-2 Drug resistance Resistance mechanism Therapeutic strategies |
| title | SARS-CoV-2 drug resistance and therapeutic approaches |
| title_full | SARS-CoV-2 drug resistance and therapeutic approaches |
| title_fullStr | SARS-CoV-2 drug resistance and therapeutic approaches |
| title_full_unstemmed | SARS-CoV-2 drug resistance and therapeutic approaches |
| title_short | SARS-CoV-2 drug resistance and therapeutic approaches |
| title_sort | sars cov 2 drug resistance and therapeutic approaches |
| topic | Antiviral drugs SARS-CoV-2 Drug resistance Resistance mechanism Therapeutic strategies |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025003603 |
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