Restless legs syndrome in Parkinson's disease and increased cardiovascular risk
ABSTRACT Restless legs syndrome (RLS) is a disorder commonly found in patients with Parkinson's disease, with descriptions for both conditions impairing dopaminergic transmission in central nervous system. Previous studies in varied populations indicate an association between the presence of RL...
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| Series: | Arquivos de Neuro-Psiquiatria |
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| _version_ | 1849307689622962176 |
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| author | Maren de Moraes e Silva Cezar Henrique Lorenzi Blenda Barreto Schneider Catherine Enk Fischer Seidel Isabela Salomé Viktor Cleto Morais Gianini Renata Ramina Pessoa Pilar Bueno Siqueira Mercer Maria Carolina Zavagna Witt |
| author_facet | Maren de Moraes e Silva Cezar Henrique Lorenzi Blenda Barreto Schneider Catherine Enk Fischer Seidel Isabela Salomé Viktor Cleto Morais Gianini Renata Ramina Pessoa Pilar Bueno Siqueira Mercer Maria Carolina Zavagna Witt |
| author_sort | Maren de Moraes e Silva |
| collection | DOAJ |
| description | ABSTRACT Restless legs syndrome (RLS) is a disorder commonly found in patients with Parkinson's disease, with descriptions for both conditions impairing dopaminergic transmission in central nervous system. Previous studies in varied populations indicate an association between the presence of RLS and increased cardiovascular risk and, so far, there are no consistent studies of this association in Parkinson's disease. Objective: To analyze the influence of RLS on cardiovascular risk in patients with Parkinson's disease. Methods: We reviewed the medical records of 202 patients diagnosed with Parkinson's disease and verified the presence of RLS, cardiovascular comorbidities, blood pressure measurements, lipid profiles and Framingham Risk Scores. Results: Statistically significant higher values of total cholesterol were found for the RLS group (mean 216.6 mg/dL), as well as for LDL cholesterol (mean 145 mg/dL). No statistical difference was found among the other factors. Conclusion: Patients with Parkinson's disease and RLS have a higher prevalence of dyslipidemia than patients without RLS, suggesting a correlation between restless legs and hyperlipidemia. It is questioned whether the dopaminergic substrate is the main factor in the genesis of the syndrome, as even with the use of dopaminergic agonists by both groups, it was possible to observe differences between groups. The hypothesis of the real interference of the syndrome treatment as a protective factor for cardiovascular risk was generated. |
| format | Article |
| id | doaj-art-21bcb843a1f54153a749e0f9803dde5c |
| institution | Kabale University |
| issn | 1678-4227 |
| language | English |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-21bcb843a1f54153a749e0f9803dde5c2025-08-20T03:54:42ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-4227761173173510.1590/0004-282x20180114S0004-282X2018001100731Restless legs syndrome in Parkinson's disease and increased cardiovascular riskMaren de Moraes e SilvaCezar Henrique LorenziBlenda Barreto SchneiderCatherine Enk Fischer SeidelIsabela SaloméViktor Cleto Morais GianiniRenata Ramina PessoaPilar Bueno Siqueira MercerMaria Carolina Zavagna WittABSTRACT Restless legs syndrome (RLS) is a disorder commonly found in patients with Parkinson's disease, with descriptions for both conditions impairing dopaminergic transmission in central nervous system. Previous studies in varied populations indicate an association between the presence of RLS and increased cardiovascular risk and, so far, there are no consistent studies of this association in Parkinson's disease. Objective: To analyze the influence of RLS on cardiovascular risk in patients with Parkinson's disease. Methods: We reviewed the medical records of 202 patients diagnosed with Parkinson's disease and verified the presence of RLS, cardiovascular comorbidities, blood pressure measurements, lipid profiles and Framingham Risk Scores. Results: Statistically significant higher values of total cholesterol were found for the RLS group (mean 216.6 mg/dL), as well as for LDL cholesterol (mean 145 mg/dL). No statistical difference was found among the other factors. Conclusion: Patients with Parkinson's disease and RLS have a higher prevalence of dyslipidemia than patients without RLS, suggesting a correlation between restless legs and hyperlipidemia. It is questioned whether the dopaminergic substrate is the main factor in the genesis of the syndrome, as even with the use of dopaminergic agonists by both groups, it was possible to observe differences between groups. The hypothesis of the real interference of the syndrome treatment as a protective factor for cardiovascular risk was generated.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018001100731&lng=en&tlng=enDoença de Parkinsonsíndrome das pernas inquietasdoenças cardiovascularesdislipidemias |
| spellingShingle | Maren de Moraes e Silva Cezar Henrique Lorenzi Blenda Barreto Schneider Catherine Enk Fischer Seidel Isabela Salomé Viktor Cleto Morais Gianini Renata Ramina Pessoa Pilar Bueno Siqueira Mercer Maria Carolina Zavagna Witt Restless legs syndrome in Parkinson's disease and increased cardiovascular risk Arquivos de Neuro-Psiquiatria Doença de Parkinson síndrome das pernas inquietas doenças cardiovasculares dislipidemias |
| title | Restless legs syndrome in Parkinson's disease and increased cardiovascular risk |
| title_full | Restless legs syndrome in Parkinson's disease and increased cardiovascular risk |
| title_fullStr | Restless legs syndrome in Parkinson's disease and increased cardiovascular risk |
| title_full_unstemmed | Restless legs syndrome in Parkinson's disease and increased cardiovascular risk |
| title_short | Restless legs syndrome in Parkinson's disease and increased cardiovascular risk |
| title_sort | restless legs syndrome in parkinson s disease and increased cardiovascular risk |
| topic | Doença de Parkinson síndrome das pernas inquietas doenças cardiovasculares dislipidemias |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018001100731&lng=en&tlng=en |
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