"Energetics of the outer retina I: Estimates of nutrient exchange and ATP generation".
Photoreceptors (PRs) are metabolically demanding and packed at high density, which presents a challenge for nutrient exchange between the associated vascular beds and the tissue. Motivated by the ambition to understand the constraints under which PRs function, in this study we have drawn together di...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0312260 |
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| author | Stella Prins Christina Kiel Alexander J E Foss Moussa A Zouache Philip J Luthert |
| author_facet | Stella Prins Christina Kiel Alexander J E Foss Moussa A Zouache Philip J Luthert |
| author_sort | Stella Prins |
| collection | DOAJ |
| description | Photoreceptors (PRs) are metabolically demanding and packed at high density, which presents a challenge for nutrient exchange between the associated vascular beds and the tissue. Motivated by the ambition to understand the constraints under which PRs function, in this study we have drawn together diverse physiological and anatomical data in order to generate estimates of the rates of ATP production per mm2 of retinal surface area. With the predictions of metabolic demand in the companion paper, we seek to develop an integrated energy budget for the outer retina. It is known that rod PR number and the extent of the choriocapillaris (CC) vascular network that supports PRs both decline with age. To set the outer retina energy budget in the context of aging we demonstrate how, at different eccentricities, decline CC density is more than matched by rod loss in a way that tends to preserve nutrient exchange per rod. Together these finds provide an integrated framework for the study of outer retinal metabolism and how it might change with age. |
| format | Article |
| id | doaj-art-21bba27b6f01471b978fb656d6f5c047 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-21bba27b6f01471b978fb656d6f5c0472025-08-20T02:44:40ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-011912e031226010.1371/journal.pone.0312260"Energetics of the outer retina I: Estimates of nutrient exchange and ATP generation".Stella PrinsChristina KielAlexander J E FossMoussa A ZouachePhilip J LuthertPhotoreceptors (PRs) are metabolically demanding and packed at high density, which presents a challenge for nutrient exchange between the associated vascular beds and the tissue. Motivated by the ambition to understand the constraints under which PRs function, in this study we have drawn together diverse physiological and anatomical data in order to generate estimates of the rates of ATP production per mm2 of retinal surface area. With the predictions of metabolic demand in the companion paper, we seek to develop an integrated energy budget for the outer retina. It is known that rod PR number and the extent of the choriocapillaris (CC) vascular network that supports PRs both decline with age. To set the outer retina energy budget in the context of aging we demonstrate how, at different eccentricities, decline CC density is more than matched by rod loss in a way that tends to preserve nutrient exchange per rod. Together these finds provide an integrated framework for the study of outer retinal metabolism and how it might change with age.https://doi.org/10.1371/journal.pone.0312260 |
| spellingShingle | Stella Prins Christina Kiel Alexander J E Foss Moussa A Zouache Philip J Luthert "Energetics of the outer retina I: Estimates of nutrient exchange and ATP generation". PLoS ONE |
| title | "Energetics of the outer retina I: Estimates of nutrient exchange and ATP generation". |
| title_full | "Energetics of the outer retina I: Estimates of nutrient exchange and ATP generation". |
| title_fullStr | "Energetics of the outer retina I: Estimates of nutrient exchange and ATP generation". |
| title_full_unstemmed | "Energetics of the outer retina I: Estimates of nutrient exchange and ATP generation". |
| title_short | "Energetics of the outer retina I: Estimates of nutrient exchange and ATP generation". |
| title_sort | energetics of the outer retina i estimates of nutrient exchange and atp generation |
| url | https://doi.org/10.1371/journal.pone.0312260 |
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