Association of life’s simple 7 with osteoarthritis risk: a cross-sectional study from NHANES 2009–2018
BackgroundThe Life’s Simple 7 (LS7) metric is a comprehensive index evaluating cardiovascular health from a holistic perspective, integrating seven cardiovascular-related health factors and behaviors. However, the relationship between LS7 and the likelihood of developing osteoarthritis (OA) remains...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-04-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1511270/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849760888946425856 |
|---|---|
| author | Teng Ma Teng Ma Zhiping Yu Zhiping Yu Wenjing Qu Xiaogeng Sun Jian Huang Wenpeng Xie Haibo Cong Haibo Cong |
| author_facet | Teng Ma Teng Ma Zhiping Yu Zhiping Yu Wenjing Qu Xiaogeng Sun Jian Huang Wenpeng Xie Haibo Cong Haibo Cong |
| author_sort | Teng Ma |
| collection | DOAJ |
| description | BackgroundThe Life’s Simple 7 (LS7) metric is a comprehensive index evaluating cardiovascular health from a holistic perspective, integrating seven cardiovascular-related health factors and behaviors. However, the relationship between LS7 and the likelihood of developing osteoarthritis (OA) remains unclear. Therefore, this study investigated the possible association between LS7 and OA.MethodsUsing data from the National Health and Nutrition Examination Survey from 2009 to 2018, 19,603 participants were included in this study. LS7 was treated as the independent variable, whereas OA served as the dependent variable. The association between LS7 and OA was assessed by performing a weighted logistic regression analysis. To evaluate the stability of the findings, subgroup analyses were conducted. Additionally, restricted cubic spline (RCS) analysis was conducted to explore potential nonlinear relationships between LS7 and OA.ResultsLS7 scores were significantly negatively correlated with OA risk (OR: 0.808, 95% CI: 0.786–0.830). Analysis of LS7 categories indicated that individuals with ideal scores had a 55.9% lower OA risk than those with poor scores (OR: 0.559, 95% CI: 0.379–0.823). Subgroup analysis demonstrated that factors such as age, gender, marital status, BMI, and blood pressure moderated the relationship between LS7 and OA in inconsistent ways. The RCS analysis revealed a significant nonlinear negative association between LS7 scores and OA risk (p-nonlinear < 0.001).ConclusionThis study suggests a nonlinear negative correlation between LS7 and OA risk, implying that better cardiovascular health may be linked to a reduced risk of developing OA. However, the relationship varies across different subgroups. |
| format | Article |
| id | doaj-art-21b8ef851bb14ec8b2f7be2dc7afa802 |
| institution | DOAJ |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-21b8ef851bb14ec8b2f7be2dc7afa8022025-08-20T03:06:13ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-04-011210.3389/fmed.2025.15112701511270Association of life’s simple 7 with osteoarthritis risk: a cross-sectional study from NHANES 2009–2018Teng Ma0Teng Ma1Zhiping Yu2Zhiping Yu3Wenjing Qu4Xiaogeng Sun5Jian Huang6Wenpeng Xie7Haibo Cong8Haibo Cong9First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, ChinaDepartment of Orthopedics, Limin Hospital of Weihai High District, Weihai, ChinaFirst Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, ChinaDepartment of Orthopedics, Limin Hospital of Weihai High District, Weihai, ChinaDepartment of Orthopedics, Limin Hospital of Weihai High District, Weihai, ChinaDepartment of Orthopedics, Limin Hospital of Weihai High District, Weihai, ChinaDepartment of Orthopedics, Limin Hospital of Weihai High District, Weihai, ChinaDepartment of Orthopedics, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, ChinaDepartment of Orthopedics, Limin Hospital of Weihai High District, Weihai, ChinaMedical Technology Innovation Center, Shandong First Medical University, Jinan, ChinaBackgroundThe Life’s Simple 7 (LS7) metric is a comprehensive index evaluating cardiovascular health from a holistic perspective, integrating seven cardiovascular-related health factors and behaviors. However, the relationship between LS7 and the likelihood of developing osteoarthritis (OA) remains unclear. Therefore, this study investigated the possible association between LS7 and OA.MethodsUsing data from the National Health and Nutrition Examination Survey from 2009 to 2018, 19,603 participants were included in this study. LS7 was treated as the independent variable, whereas OA served as the dependent variable. The association between LS7 and OA was assessed by performing a weighted logistic regression analysis. To evaluate the stability of the findings, subgroup analyses were conducted. Additionally, restricted cubic spline (RCS) analysis was conducted to explore potential nonlinear relationships between LS7 and OA.ResultsLS7 scores were significantly negatively correlated with OA risk (OR: 0.808, 95% CI: 0.786–0.830). Analysis of LS7 categories indicated that individuals with ideal scores had a 55.9% lower OA risk than those with poor scores (OR: 0.559, 95% CI: 0.379–0.823). Subgroup analysis demonstrated that factors such as age, gender, marital status, BMI, and blood pressure moderated the relationship between LS7 and OA in inconsistent ways. The RCS analysis revealed a significant nonlinear negative association between LS7 scores and OA risk (p-nonlinear < 0.001).ConclusionThis study suggests a nonlinear negative correlation between LS7 and OA risk, implying that better cardiovascular health may be linked to a reduced risk of developing OA. However, the relationship varies across different subgroups.https://www.frontiersin.org/articles/10.3389/fmed.2025.1511270/fullosteoarthritisLife’s Simple 7NHANEScardiovascular healthcross-sectional studies |
| spellingShingle | Teng Ma Teng Ma Zhiping Yu Zhiping Yu Wenjing Qu Xiaogeng Sun Jian Huang Wenpeng Xie Haibo Cong Haibo Cong Association of life’s simple 7 with osteoarthritis risk: a cross-sectional study from NHANES 2009–2018 Frontiers in Medicine osteoarthritis Life’s Simple 7 NHANES cardiovascular health cross-sectional studies |
| title | Association of life’s simple 7 with osteoarthritis risk: a cross-sectional study from NHANES 2009–2018 |
| title_full | Association of life’s simple 7 with osteoarthritis risk: a cross-sectional study from NHANES 2009–2018 |
| title_fullStr | Association of life’s simple 7 with osteoarthritis risk: a cross-sectional study from NHANES 2009–2018 |
| title_full_unstemmed | Association of life’s simple 7 with osteoarthritis risk: a cross-sectional study from NHANES 2009–2018 |
| title_short | Association of life’s simple 7 with osteoarthritis risk: a cross-sectional study from NHANES 2009–2018 |
| title_sort | association of life s simple 7 with osteoarthritis risk a cross sectional study from nhanes 2009 2018 |
| topic | osteoarthritis Life’s Simple 7 NHANES cardiovascular health cross-sectional studies |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1511270/full |
| work_keys_str_mv | AT tengma associationoflifessimple7withosteoarthritisriskacrosssectionalstudyfromnhanes20092018 AT tengma associationoflifessimple7withosteoarthritisriskacrosssectionalstudyfromnhanes20092018 AT zhipingyu associationoflifessimple7withosteoarthritisriskacrosssectionalstudyfromnhanes20092018 AT zhipingyu associationoflifessimple7withosteoarthritisriskacrosssectionalstudyfromnhanes20092018 AT wenjingqu associationoflifessimple7withosteoarthritisriskacrosssectionalstudyfromnhanes20092018 AT xiaogengsun associationoflifessimple7withosteoarthritisriskacrosssectionalstudyfromnhanes20092018 AT jianhuang associationoflifessimple7withosteoarthritisriskacrosssectionalstudyfromnhanes20092018 AT wenpengxie associationoflifessimple7withosteoarthritisriskacrosssectionalstudyfromnhanes20092018 AT haibocong associationoflifessimple7withosteoarthritisriskacrosssectionalstudyfromnhanes20092018 AT haibocong associationoflifessimple7withosteoarthritisriskacrosssectionalstudyfromnhanes20092018 |