Intracellular Inclusions Induced by Patient-Derived and Amplified α-Synuclein Aggregates Are Morphologically Indistinguishable

Intracellular Inclusions Induced by Patient-Derived and Amplified α-Synuclein Aggregates Are Morphologically Indistinguishable

Lewy Body Disease (LBD) and Multiple System Atrophy (MSA) are synucleinopathies with distinct prognoses and neuropathologies, however, with overlapping clinical symptoms. Different disease characteristics are proposed to be determined by distinct conformations of alpha-synuclein (α-Syn) aggregates,...

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Bibliographic Details
Main Authors: Rabab Al-Lahham, Mark E. Corkins, Mohd Ishtikhar, Prakruti Rabadia, Santiago Ramirez, Victor Banerjee, Mohammad Shahnawaz
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Cells
Subjects:
Parkinson’s disease
multiple system atrophy
α-synuclein
aggregation
SAA
biosensor cells
Online Access:https://www.mdpi.com/2073-4409/14/10/684
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