Thrombotic storm, hemostasis disorders and thromboinflammation in COVID-19
The rate of thrombosis and disseminated intravascular coagulation (DIC) has been increasing in COVID-19 patients. Key features related to such condition include minimal or no risk of bleeding, moderate thrombocytopenia, high plasma fibrinogen as well as complement components level in the areas of th...
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2021-11-01
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| Series: | Акушерство, гинекология и репродукция |
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| Online Access: | https://www.gynecology.su/jour/article/view/1081 |
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| author | A. D. Makatsariya E. V. Slukhanchuk V. O. Bitsadze J. Kh. Khizroeva M. V. Tretyakova A. S. Shkoda S. V. Akinshina N. A. Makatsariya V. I. Tsibizova J.-C. Gris I. Elalamy С. Ay E. Grandone |
| author_facet | A. D. Makatsariya E. V. Slukhanchuk V. O. Bitsadze J. Kh. Khizroeva M. V. Tretyakova A. S. Shkoda S. V. Akinshina N. A. Makatsariya V. I. Tsibizova J.-C. Gris I. Elalamy С. Ay E. Grandone |
| author_sort | A. D. Makatsariya |
| collection | DOAJ |
| description | The rate of thrombosis and disseminated intravascular coagulation (DIC) has been increasing in COVID-19 patients. Key features related to such condition include minimal or no risk of bleeding, moderate thrombocytopenia, high plasma fibrinogen as well as complement components level in the areas of thrombotic microangiopathy. The clinical picture is not typical for classic DIC. This review systematizes the pathogenetic mechanisms of hypercoagulation in sepsis and its extreme forms in patients with COVID-19. The latter consist of the thrombosis-related immune mechanisms, the complement activation, the macrophage activation syndrome, the formation of antiphospholipid antibodies, the hyperferritinemia, and the dysregulation of the renin-angiotensin system. Taking into consideration the pathogenetic mechanisms, the biomarkers had been identified related to the prognosis of the disease development. Patients with pre-existing cardiovascular disease and other risk factors, including obesity, diabetes, hypertension, and aging pose the peak risk of dying from COVID-19. We also summarize new data on platelet and endothelial dysfunction, immunothrombosis, and, as a result, thrombotic storm as essential components of COVID-19 severe features. |
| format | Article |
| id | doaj-art-21b15844934647a79baecfda4f9d0414 |
| institution | DOAJ |
| issn | 2313-7347 2500-3194 |
| language | Russian |
| publishDate | 2021-11-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Акушерство, гинекология и репродукция |
| spelling | doaj-art-21b15844934647a79baecfda4f9d04142025-08-20T02:53:55ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942021-11-0115549951410.17749/2313-7347/ob.gyn.rep.2021.247672Thrombotic storm, hemostasis disorders and thromboinflammation in COVID-19A. D. Makatsariya0E. V. Slukhanchuk1V. O. Bitsadze2J. Kh. Khizroeva3M. V. Tretyakova4A. S. Shkoda5S. V. Akinshina6N. A. Makatsariya7V. I. Tsibizova8J.-C. Gris9I. Elalamy10С. Ay11E. Grandone12Sechenov UniversitySechenov University; Petrovsky National Research Centre of SurgerySechenov UniversitySechenov University«Medical Center» LLCVorokhobov City Clinical Hospital № 67, Moscow Healthcare Department«Medical Centre for Women» LLCSechenov UniversityAlmazov National Medical Research Centre, Health Ministry of Russian FederationSechenov University; University of MontpellierSechenov University; Medicine Sorbonne University; Hospital TenonUniversity of ViennaSechenov University; Research Center «Casa Sollievo della Sofferenza»The rate of thrombosis and disseminated intravascular coagulation (DIC) has been increasing in COVID-19 patients. Key features related to such condition include minimal or no risk of bleeding, moderate thrombocytopenia, high plasma fibrinogen as well as complement components level in the areas of thrombotic microangiopathy. The clinical picture is not typical for classic DIC. This review systematizes the pathogenetic mechanisms of hypercoagulation in sepsis and its extreme forms in patients with COVID-19. The latter consist of the thrombosis-related immune mechanisms, the complement activation, the macrophage activation syndrome, the formation of antiphospholipid antibodies, the hyperferritinemia, and the dysregulation of the renin-angiotensin system. Taking into consideration the pathogenetic mechanisms, the biomarkers had been identified related to the prognosis of the disease development. Patients with pre-existing cardiovascular disease and other risk factors, including obesity, diabetes, hypertension, and aging pose the peak risk of dying from COVID-19. We also summarize new data on platelet and endothelial dysfunction, immunothrombosis, and, as a result, thrombotic storm as essential components of COVID-19 severe features.https://www.gynecology.su/jour/article/view/1081thrombotic stormthrombus inflammationcovid-19cytokine stormneutrophil extracellular trapsnetsendotheliopathy |
| spellingShingle | A. D. Makatsariya E. V. Slukhanchuk V. O. Bitsadze J. Kh. Khizroeva M. V. Tretyakova A. S. Shkoda S. V. Akinshina N. A. Makatsariya V. I. Tsibizova J.-C. Gris I. Elalamy С. Ay E. Grandone Thrombotic storm, hemostasis disorders and thromboinflammation in COVID-19 Акушерство, гинекология и репродукция thrombotic storm thrombus inflammation covid-19 cytokine storm neutrophil extracellular traps nets endotheliopathy |
| title | Thrombotic storm, hemostasis disorders and thromboinflammation in COVID-19 |
| title_full | Thrombotic storm, hemostasis disorders and thromboinflammation in COVID-19 |
| title_fullStr | Thrombotic storm, hemostasis disorders and thromboinflammation in COVID-19 |
| title_full_unstemmed | Thrombotic storm, hemostasis disorders and thromboinflammation in COVID-19 |
| title_short | Thrombotic storm, hemostasis disorders and thromboinflammation in COVID-19 |
| title_sort | thrombotic storm hemostasis disorders and thromboinflammation in covid 19 |
| topic | thrombotic storm thrombus inflammation covid-19 cytokine storm neutrophil extracellular traps nets endotheliopathy |
| url | https://www.gynecology.su/jour/article/view/1081 |
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