Identification of pancreatic cancer-specific protease substrates for protease-dependent targeted delivery
Abstract Pancreatic ductal adenocarcinoma (PDAC) presents significant challenges due to the inadequacy of existing chemotherapeutics, which often result in toxicity-dependent dose limitations and premature cessation of therapy. Targeted delivery of therapeutic molecules offers a promising solution....
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| Main Authors: | Etienne J. Slapak, Danny A. Zwijnenburg, Jan Koster, Maarten F. Bijlsma, C. Arnold Spek |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2024-11-01
|
| Series: | Oncogenesis |
| Online Access: | https://doi.org/10.1038/s41389-024-00542-1 |
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