Non-HDL cholesterol: A valid surrogate marker to apolipoprotein b100 in type 2 diabetes mellitus patients in assessment of risk of cardiovascular diseases
Background: Considering the cardiovascular complications in Type 2 Diabetes Mellitus (T2DM) despite normal Total Cholesterol (TC) and Low Density Lipoprotein (LDL) levels, Non High Density Lipoprotein (non-HDL-C) and Apolipoprotein B (ApoB) were added as secondary targets and have been increasingly...
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Krishna Vishwa Vidyapeeth (Deemed to be University), Karad
2024-07-01
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| Series: | Journal of Krishna Institute of Medical Sciences University |
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| Online Access: | https://www.jkimsu.com/jkimsu-vol13no3/JKIMSU,%20Vol.%2013,%20No.%203,%20July-September%202024%20Page%20146-154.pdf |
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| author | Vidyashree Lakshmi D Prashanth D Indushree T Hamsaveena |
| author_facet | Vidyashree Lakshmi D Prashanth D Indushree T Hamsaveena |
| author_sort | Vidyashree |
| collection | DOAJ |
| description | Background: Considering the cardiovascular complications in Type 2 Diabetes Mellitus (T2DM) despite normal Total Cholesterol (TC) and Low Density Lipoprotein (LDL) levels, Non High Density Lipoprotein (non-HDL-C) and
Apolipoprotein B (ApoB) were added as secondary targets and have been increasingly acknowledged as measures of risk estimation for developing atherosclerotic Cardiovascular Disease (CVD). Aim and Objectives: To study the
correlation between ApoB100 and non-HDL-C in assessing the risk of cardiovascular complications in T2DM patients. Material and Methods: A total of 90 T2DM patients attending Medicine and Cardiology outpatient departments were recruited for the study. They were categorised into 2 groups -T2DM with CVD and T2DM without CVD. Three ml of fasting venous blood sample was taken from each patient and fasting blood sugar, TC, triglycerides, HDL-C and ApoB were estimated on VITROS 5600 Integrated Autoanalyser. LDL-C was calculated using Friedewald formula and non-HDL-C was calculated by subtracting HDL-C from TC. Results: The levels of ApoB and non-HDL-C in T2DM patients with CVD and without CVD were found to be significant with p < 0.001. There was a significant
correlation between ApoB and non-HDL-C values in both the groups as analysed by Karl Pearson's correlation coefficient(p <0.001). After linear regression analysis, non-HDL-C was found to have a strong correlation with ApoB100 in both the groups with r of 0.753 and 0.215 respectively (p < 0.001). Conclusion: The present study has demonstrated a strong correlation between ApoB and non-HDL-C in T2DM patients with or without CVD and hence can substitute for each other. |
| format | Article |
| id | doaj-art-21ae0a62f7c340bf9036b7d406c9c788 |
| institution | Kabale University |
| issn | 2231-4261 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Krishna Vishwa Vidyapeeth (Deemed to be University), Karad |
| record_format | Article |
| series | Journal of Krishna Institute of Medical Sciences University |
| spelling | doaj-art-21ae0a62f7c340bf9036b7d406c9c7882025-02-02T16:21:48ZengKrishna Vishwa Vidyapeeth (Deemed to be University), KaradJournal of Krishna Institute of Medical Sciences University2231-42612024-07-01133146154Non-HDL cholesterol: A valid surrogate marker to apolipoprotein b100 in type 2 diabetes mellitus patients in assessment of risk of cardiovascular diseasesVidyashree0Lakshmi D1Prashanth D2Indushree T3 Hamsaveena4Department of General Medicine, Sapthagiri Institute of Medical Sciences & Research Centre, Bangalore-560090 (Karnataka) IndiaDepartment of Biochemistry, Siddaganga Medical College & Research Institute, Tumkur-572102 (Karnataka) IndiaDepartment of Pharmacology, Siddaganga Medical College & Research Institute, Tumkur-572102 (Karnataka) IndiaDepartment of Pharmacology, Siddaganga Medical College & Research Institute, Tumkur-572102 (Karnataka) IndiaDepartment of Biochemistry, Siddaganga Medical College & Research Institute, Tumkur-572102 (Karnataka) IndiaBackground: Considering the cardiovascular complications in Type 2 Diabetes Mellitus (T2DM) despite normal Total Cholesterol (TC) and Low Density Lipoprotein (LDL) levels, Non High Density Lipoprotein (non-HDL-C) and Apolipoprotein B (ApoB) were added as secondary targets and have been increasingly acknowledged as measures of risk estimation for developing atherosclerotic Cardiovascular Disease (CVD). Aim and Objectives: To study the correlation between ApoB100 and non-HDL-C in assessing the risk of cardiovascular complications in T2DM patients. Material and Methods: A total of 90 T2DM patients attending Medicine and Cardiology outpatient departments were recruited for the study. They were categorised into 2 groups -T2DM with CVD and T2DM without CVD. Three ml of fasting venous blood sample was taken from each patient and fasting blood sugar, TC, triglycerides, HDL-C and ApoB were estimated on VITROS 5600 Integrated Autoanalyser. LDL-C was calculated using Friedewald formula and non-HDL-C was calculated by subtracting HDL-C from TC. Results: The levels of ApoB and non-HDL-C in T2DM patients with CVD and without CVD were found to be significant with p < 0.001. There was a significant correlation between ApoB and non-HDL-C values in both the groups as analysed by Karl Pearson's correlation coefficient(p <0.001). After linear regression analysis, non-HDL-C was found to have a strong correlation with ApoB100 in both the groups with r of 0.753 and 0.215 respectively (p < 0.001). Conclusion: The present study has demonstrated a strong correlation between ApoB and non-HDL-C in T2DM patients with or without CVD and hence can substitute for each other.https://www.jkimsu.com/jkimsu-vol13no3/JKIMSU,%20Vol.%2013,%20No.%203,%20July-September%202024%20Page%20146-154.pdfapob100atherosclerosiscardiovascular diseasediabetes mellitusnon hdl cholesterol |
| spellingShingle | Vidyashree Lakshmi D Prashanth D Indushree T Hamsaveena Non-HDL cholesterol: A valid surrogate marker to apolipoprotein b100 in type 2 diabetes mellitus patients in assessment of risk of cardiovascular diseases Journal of Krishna Institute of Medical Sciences University apob100 atherosclerosis cardiovascular disease diabetes mellitus non hdl cholesterol |
| title | Non-HDL cholesterol: A valid surrogate marker to apolipoprotein b100 in type 2 diabetes mellitus patients in assessment of risk of cardiovascular diseases |
| title_full | Non-HDL cholesterol: A valid surrogate marker to apolipoprotein b100 in type 2 diabetes mellitus patients in assessment of risk of cardiovascular diseases |
| title_fullStr | Non-HDL cholesterol: A valid surrogate marker to apolipoprotein b100 in type 2 diabetes mellitus patients in assessment of risk of cardiovascular diseases |
| title_full_unstemmed | Non-HDL cholesterol: A valid surrogate marker to apolipoprotein b100 in type 2 diabetes mellitus patients in assessment of risk of cardiovascular diseases |
| title_short | Non-HDL cholesterol: A valid surrogate marker to apolipoprotein b100 in type 2 diabetes mellitus patients in assessment of risk of cardiovascular diseases |
| title_sort | non hdl cholesterol a valid surrogate marker to apolipoprotein b100 in type 2 diabetes mellitus patients in assessment of risk of cardiovascular diseases |
| topic | apob100 atherosclerosis cardiovascular disease diabetes mellitus non hdl cholesterol |
| url | https://www.jkimsu.com/jkimsu-vol13no3/JKIMSU,%20Vol.%2013,%20No.%203,%20July-September%202024%20Page%20146-154.pdf |
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