Beyond the dichotomy: understanding the overlap between atopic dermatitis and psoriasis
Atopic dermatitis and psoriasis have traditionally been considered distinct inflammatory skin diseases with unique pathogenic mechanisms. However, accumulating evidence suggests significant overlap in their immunological pathways, metabolic features, and microbiome characteristics, challenging this...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1541776/full |
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| author | Mengmeng Li Jiangyi Wang Qingfeng Liu Youqing Liu Wenyao Mi Wei Li Wei Li Jingyi Li |
| author_facet | Mengmeng Li Jiangyi Wang Qingfeng Liu Youqing Liu Wenyao Mi Wei Li Wei Li Jingyi Li |
| author_sort | Mengmeng Li |
| collection | DOAJ |
| description | Atopic dermatitis and psoriasis have traditionally been considered distinct inflammatory skin diseases with unique pathogenic mechanisms. However, accumulating evidence suggests significant overlap in their immunological pathways, metabolic features, and microbiome characteristics, challenging this conventional dichotomy. This review comprehensively examines the complex relationship between psoriasis and atopic dermatitis, with particular emphasis on their shared and distinct pathogenic mechanisms. We analyze the immunological networks, metabolic pathways, and microbial factors contributing to their development and progression. The review expands upon the disease spectrum hypothesis and discusses the nomenclature for conditions exhibiting features of both diseases. We critically evaluate the clinical and histopathological characteristics of concomitant psoriasis and atopic dermatitis, highlighting recent advances in molecular diagnostics for accurate disease differentiation. Importantly, we propose standardized diagnostic criteria for psoriasis dermatitis and examine current therapeutic strategies for managing overlapping conditions. Recent developments in targeted therapies and their implications for treatment selection are thoroughly discussed. By synthesizing current evidence and identifying knowledge gaps, this review provides insights into the complex interplay between psoriasis and atopic dermatitis, aiming to guide clinical decision-making and future research directions in this evolving field. |
| format | Article |
| id | doaj-art-21a4045059a94cb4a40655675784df77 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-21a4045059a94cb4a40655675784df772025-02-10T06:48:46ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-02-011610.3389/fimmu.2025.15417761541776Beyond the dichotomy: understanding the overlap between atopic dermatitis and psoriasisMengmeng Li0Jiangyi Wang1Qingfeng Liu2Youqing Liu3Wenyao Mi4Wei Li5Wei Li6Jingyi Li7Department of Dermatology and Venerology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Dermatology and Venerology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Dermatology and Venerology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Dermatology and Venerology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Dermatology and Venerology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Dermatology and Venerology, West China Hospital, Sichuan University, Chengdu, ChinaRare Diseases Center, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Dermatology and Venerology, West China Hospital, Sichuan University, Chengdu, ChinaAtopic dermatitis and psoriasis have traditionally been considered distinct inflammatory skin diseases with unique pathogenic mechanisms. However, accumulating evidence suggests significant overlap in their immunological pathways, metabolic features, and microbiome characteristics, challenging this conventional dichotomy. This review comprehensively examines the complex relationship between psoriasis and atopic dermatitis, with particular emphasis on their shared and distinct pathogenic mechanisms. We analyze the immunological networks, metabolic pathways, and microbial factors contributing to their development and progression. The review expands upon the disease spectrum hypothesis and discusses the nomenclature for conditions exhibiting features of both diseases. We critically evaluate the clinical and histopathological characteristics of concomitant psoriasis and atopic dermatitis, highlighting recent advances in molecular diagnostics for accurate disease differentiation. Importantly, we propose standardized diagnostic criteria for psoriasis dermatitis and examine current therapeutic strategies for managing overlapping conditions. Recent developments in targeted therapies and their implications for treatment selection are thoroughly discussed. By synthesizing current evidence and identifying knowledge gaps, this review provides insights into the complex interplay between psoriasis and atopic dermatitis, aiming to guide clinical decision-making and future research directions in this evolving field.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1541776/fulloverlapatopic dermatitispsoriasispsoriasis dermatitisimmunological networks |
| spellingShingle | Mengmeng Li Jiangyi Wang Qingfeng Liu Youqing Liu Wenyao Mi Wei Li Wei Li Jingyi Li Beyond the dichotomy: understanding the overlap between atopic dermatitis and psoriasis Frontiers in Immunology overlap atopic dermatitis psoriasis psoriasis dermatitis immunological networks |
| title | Beyond the dichotomy: understanding the overlap between atopic dermatitis and psoriasis |
| title_full | Beyond the dichotomy: understanding the overlap between atopic dermatitis and psoriasis |
| title_fullStr | Beyond the dichotomy: understanding the overlap between atopic dermatitis and psoriasis |
| title_full_unstemmed | Beyond the dichotomy: understanding the overlap between atopic dermatitis and psoriasis |
| title_short | Beyond the dichotomy: understanding the overlap between atopic dermatitis and psoriasis |
| title_sort | beyond the dichotomy understanding the overlap between atopic dermatitis and psoriasis |
| topic | overlap atopic dermatitis psoriasis psoriasis dermatitis immunological networks |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1541776/full |
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