The Immunologic Role of Gut Microbiota in Patients with Chronic HBV Infection
Hepatitis B can cause acute or chronic liver damage due to hepatitis B virus (HBV) infection. Cirrhosis or hepatocellular carcinoma (HCC) caused by chronic HBV infection often leads to increased mortality. However, the gut and liver have the same embryonic origin; therefore, a close relationship mus...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/2361963 |
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| author | Ruilin Yang Yao Xu Zhifeng Dai Xuhong Lin Huichao Wang |
| author_facet | Ruilin Yang Yao Xu Zhifeng Dai Xuhong Lin Huichao Wang |
| author_sort | Ruilin Yang |
| collection | DOAJ |
| description | Hepatitis B can cause acute or chronic liver damage due to hepatitis B virus (HBV) infection. Cirrhosis or hepatocellular carcinoma (HCC) caused by chronic HBV infection often leads to increased mortality. However, the gut and liver have the same embryonic origin; therefore, a close relationship must exist in terms of anatomy and function, and the gut microbiota plays an important role in host metabolic and immune modulation. It is believed that structural changes in the gut microbiota, bacterial translocation, and the resulting immune injury may affect the occurrence and development of liver inflammation caused by chronic HBV infection based on the in-depth cognition of the concept of the “gut-liver axis” and the progress in intestinal microecology. This review aims to summarize and discuss the immunologic role of the gut microbiota in chronic HBV infection. |
| format | Article |
| id | doaj-art-21a10d16c9364bb4a3819075fe4e4bfd |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-21a10d16c9364bb4a3819075fe4e4bfd2025-08-20T02:04:07ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/23619632361963The Immunologic Role of Gut Microbiota in Patients with Chronic HBV InfectionRuilin Yang0Yao Xu1Zhifeng Dai2Xuhong Lin3Huichao Wang4Department of Clinical Laboratory, Translational Medicine Center, Huaihe Hospital Affiliated to Henan University, Kaifeng, Henan 475000, ChinaDepartment of Clinical Laboratory, Translational Medicine Center, Huaihe Hospital Affiliated to Henan University, Kaifeng, Henan 475000, ChinaDepartment of Clinical Laboratory, Translational Medicine Center, Huaihe Hospital Affiliated to Henan University, Kaifeng, Henan 475000, ChinaDepartment of Clinical Laboratory, Translational Medicine Center, Huaihe Hospital Affiliated to Henan University, Kaifeng, Henan 475000, ChinaDepartment of Nephrology, First Affiliated Hospital of Henan University, Kaifeng, Henan 475000, ChinaHepatitis B can cause acute or chronic liver damage due to hepatitis B virus (HBV) infection. Cirrhosis or hepatocellular carcinoma (HCC) caused by chronic HBV infection often leads to increased mortality. However, the gut and liver have the same embryonic origin; therefore, a close relationship must exist in terms of anatomy and function, and the gut microbiota plays an important role in host metabolic and immune modulation. It is believed that structural changes in the gut microbiota, bacterial translocation, and the resulting immune injury may affect the occurrence and development of liver inflammation caused by chronic HBV infection based on the in-depth cognition of the concept of the “gut-liver axis” and the progress in intestinal microecology. This review aims to summarize and discuss the immunologic role of the gut microbiota in chronic HBV infection.http://dx.doi.org/10.1155/2018/2361963 |
| spellingShingle | Ruilin Yang Yao Xu Zhifeng Dai Xuhong Lin Huichao Wang The Immunologic Role of Gut Microbiota in Patients with Chronic HBV Infection Journal of Immunology Research |
| title | The Immunologic Role of Gut Microbiota in Patients with Chronic HBV Infection |
| title_full | The Immunologic Role of Gut Microbiota in Patients with Chronic HBV Infection |
| title_fullStr | The Immunologic Role of Gut Microbiota in Patients with Chronic HBV Infection |
| title_full_unstemmed | The Immunologic Role of Gut Microbiota in Patients with Chronic HBV Infection |
| title_short | The Immunologic Role of Gut Microbiota in Patients with Chronic HBV Infection |
| title_sort | immunologic role of gut microbiota in patients with chronic hbv infection |
| url | http://dx.doi.org/10.1155/2018/2361963 |
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