Frailty and Cardiovascular Health
The incidence of frailty and cardiovascular disease (CVD) increases as the population ages. There is a bidirectional relationship between frailty and CVD, and both conditions share several risk factors and underlying biological mechanisms. Frailty has been established as an independent prognostic ma...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-08-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.123.031736 |
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| _version_ | 1849725320831172608 |
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| author | Kirstyn James Yasser Jamil Manish Kumar Min J. Kwak Michael G. Nanna Saadia Qazi Aaron L. Troy Jawad H. Butt Abdulla A. Damluji Daniel E. Forman Ariela R. Orkaby |
| author_facet | Kirstyn James Yasser Jamil Manish Kumar Min J. Kwak Michael G. Nanna Saadia Qazi Aaron L. Troy Jawad H. Butt Abdulla A. Damluji Daniel E. Forman Ariela R. Orkaby |
| author_sort | Kirstyn James |
| collection | DOAJ |
| description | The incidence of frailty and cardiovascular disease (CVD) increases as the population ages. There is a bidirectional relationship between frailty and CVD, and both conditions share several risk factors and underlying biological mechanisms. Frailty has been established as an independent prognostic marker in patients with CVD. Moreover, its presence significantly influences both primary and secondary prevention strategies for adults with CVD while also posing a barrier to the inclusion of these patients in pivotal clinical trials and advanced cardiac interventions. This review discusses the current knowledge base on the relationship between frailty and CVD, how managing CVD risk factors can modify frailty, the influence of frailty on CVD management, and future directions for frailty detection and modification in patients with CVD. |
| format | Article |
| id | doaj-art-219bc40fcc31410bb0a4f7aadbe29017 |
| institution | DOAJ |
| issn | 2047-9980 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj-art-219bc40fcc31410bb0a4f7aadbe290172025-08-20T03:10:29ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802024-08-01131510.1161/JAHA.123.031736Frailty and Cardiovascular HealthKirstyn James0Yasser Jamil1Manish Kumar2Min J. Kwak3Michael G. Nanna4Saadia Qazi5Aaron L. Troy6Jawad H. Butt7Abdulla A. Damluji8Daniel E. Forman9Ariela R. Orkaby10Department of Geriatric Medicine Cork University Hospital Cork IrelandDepartment of Internal Medicine Yale University School of Medicine New Haven CT USAUniversity of Connecticut Hartford CT USAUniversity of Texas Health Science Center at Houston TX USADepartment of Internal Medicine Yale University School of Medicine New Haven CT USAVA Boston Healthcare System Boston MA USADepartment of Medicine Beth Israel Deaconess Medical Center Boston MA USABritish Heart Foundation Cardiovascular Research Centre University of Glasgow UKJohns Hopkins University School of Medicine Baltimore MD USADepartment of Medicine (Geriatrics and Cardiology) University of Pittsburgh PA USAVA Boston Healthcare System Boston MA USAThe incidence of frailty and cardiovascular disease (CVD) increases as the population ages. There is a bidirectional relationship between frailty and CVD, and both conditions share several risk factors and underlying biological mechanisms. Frailty has been established as an independent prognostic marker in patients with CVD. Moreover, its presence significantly influences both primary and secondary prevention strategies for adults with CVD while also posing a barrier to the inclusion of these patients in pivotal clinical trials and advanced cardiac interventions. This review discusses the current knowledge base on the relationship between frailty and CVD, how managing CVD risk factors can modify frailty, the influence of frailty on CVD management, and future directions for frailty detection and modification in patients with CVD.https://www.ahajournals.org/doi/10.1161/JAHA.123.031736agingcardiovascular diseasescardiovascular interventionsfrailtygeriatric syndromesprimary prevention |
| spellingShingle | Kirstyn James Yasser Jamil Manish Kumar Min J. Kwak Michael G. Nanna Saadia Qazi Aaron L. Troy Jawad H. Butt Abdulla A. Damluji Daniel E. Forman Ariela R. Orkaby Frailty and Cardiovascular Health Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease aging cardiovascular diseases cardiovascular interventions frailty geriatric syndromes primary prevention |
| title | Frailty and Cardiovascular Health |
| title_full | Frailty and Cardiovascular Health |
| title_fullStr | Frailty and Cardiovascular Health |
| title_full_unstemmed | Frailty and Cardiovascular Health |
| title_short | Frailty and Cardiovascular Health |
| title_sort | frailty and cardiovascular health |
| topic | aging cardiovascular diseases cardiovascular interventions frailty geriatric syndromes primary prevention |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.123.031736 |
| work_keys_str_mv | AT kirstynjames frailtyandcardiovascularhealth AT yasserjamil frailtyandcardiovascularhealth AT manishkumar frailtyandcardiovascularhealth AT minjkwak frailtyandcardiovascularhealth AT michaelgnanna frailtyandcardiovascularhealth AT saadiaqazi frailtyandcardiovascularhealth AT aaronltroy frailtyandcardiovascularhealth AT jawadhbutt frailtyandcardiovascularhealth AT abdullaadamluji frailtyandcardiovascularhealth AT danieleforman frailtyandcardiovascularhealth AT arielarorkaby frailtyandcardiovascularhealth |