Diagnostic accuracy of PfHRP2-based malaria rapid diagnostic tests and antigenemia persistence in Kenyan children from a holoendemic region: implications for case management and surveillance

Diagnostic accuracy of PfHRP2-based malaria rapid diagnostic tests and antigenemia persistence in Kenyan children from a holoendemic region: implications for case management and surveillance

Malaria remains a significant cause of childhood morbidity and mortality, with Plasmodium falciparum Histidine-Rich Protein 2 (PfHRP2)-based malaria rapid diagnostic tests (mRDTs) widely used in endemic regions where microscopy is sometimes not feasible. While these tests offer high sensitivity, per...

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Bibliographic Details
Main Authors: Sharley A. Wasena, Clinton O. Onyango, Shamim W. Osata, Samuel B. Anyona, Evans Raballah, Ivy Hurwitz, Philip D. Seidenberg, Collins Ouma, Qiuying Cheng, Kristan A. Schneider, Douglas J. Perkins
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Experimental Biology and Medicine
Subjects:
malaria diagnosis
Plasmodium falciparum
histidine rich protein
PfHRP2
mRDT
Online Access:https://www.ebm-journal.org/articles/10.3389/ebm.2025.10585/full
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