GENE EXPRESSION DYNAMICS IN PATIENTS WITH SEVERE THERAPY-RESISTANT ASTHMA DURING TREATMENT PERIOD
Introduction: The leading mechanisms and causes of severe therapy resistant asthma are poorly understood. The aim of this study was to define global patterns of gene expression in adults with severe therapy-resistant asthma in dynamic during treatment period.Methods: Performed 24-week prospective in...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2014-02-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/16 |
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| author | Ye. S. Kulikov L. M. Ogorodova M. B. Freidin I. V. Saltikova I. A. Deyev P. A. Selivanova |
| author_facet | Ye. S. Kulikov L. M. Ogorodova M. B. Freidin I. V. Saltikova I. A. Deyev P. A. Selivanova |
| author_sort | Ye. S. Kulikov |
| collection | DOAJ |
| description | Introduction: The leading mechanisms and causes of severe therapy resistant asthma are poorly understood. The aim of this study was to define global patterns of gene expression in adults with severe therapy-resistant asthma in dynamic during treatment period.Methods: Performed 24-week prospective interventional study in parallel groups. Severe asthma patients was aposterior divided at therapy sensitive and resistant patients according to ATS criteria. Global transcriptome profile was characterized using the Affymetrix HuGene ST1.0 chip. Cluster analysis was performed.Results and conclusion: According to our data several mechanisms of therapy resistance may be considered: increased levels of nitric oxide and beta2-agonists nitration, dysregulation of endogenous steroids secretion and involvement in the pathogenesis of Staphylococcus aureus. Absence of suppression of gene expression KEGG-pathway “asthma" may reflect the low efficiency or long period of anti-inflammatory therapy effect realization. |
| format | Article |
| id | doaj-art-2191fbb3c03444fb87f9a8f76fa1db15 |
| institution | Kabale University |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2014-02-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-2191fbb3c03444fb87f9a8f76fa1db152025-08-20T03:38:08ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842014-02-01131475510.20538/1682-0363-2014-1-47-5516GENE EXPRESSION DYNAMICS IN PATIENTS WITH SEVERE THERAPY-RESISTANT ASTHMA DURING TREATMENT PERIODYe. S. Kulikov0L. M. Ogorodova1M. B. Freidin2I. V. Saltikova3I. A. Deyev4P. A. Selivanova5Siberian State Medical University, TomskSiberian State Medical University, TomskResearch Institute of Medical Genetics, Siberian Branch of the Russian Academy of Medical Sciences, TomskSiberian State Medical University, TomskSiberian State Medical University, TomskSiberian State Medical University, TomskIntroduction: The leading mechanisms and causes of severe therapy resistant asthma are poorly understood. The aim of this study was to define global patterns of gene expression in adults with severe therapy-resistant asthma in dynamic during treatment period.Methods: Performed 24-week prospective interventional study in parallel groups. Severe asthma patients was aposterior divided at therapy sensitive and resistant patients according to ATS criteria. Global transcriptome profile was characterized using the Affymetrix HuGene ST1.0 chip. Cluster analysis was performed.Results and conclusion: According to our data several mechanisms of therapy resistance may be considered: increased levels of nitric oxide and beta2-agonists nitration, dysregulation of endogenous steroids secretion and involvement in the pathogenesis of Staphylococcus aureus. Absence of suppression of gene expression KEGG-pathway “asthma" may reflect the low efficiency or long period of anti-inflammatory therapy effect realization.https://bulletin.ssmu.ru/jour/article/view/16bronchial asthmatherapysevere bronchial asthmatherapy resistancemolecular mechanisms |
| spellingShingle | Ye. S. Kulikov L. M. Ogorodova M. B. Freidin I. V. Saltikova I. A. Deyev P. A. Selivanova GENE EXPRESSION DYNAMICS IN PATIENTS WITH SEVERE THERAPY-RESISTANT ASTHMA DURING TREATMENT PERIOD Бюллетень сибирской медицины bronchial asthma therapy severe bronchial asthma therapy resistance molecular mechanisms |
| title | GENE EXPRESSION DYNAMICS IN PATIENTS WITH SEVERE THERAPY-RESISTANT ASTHMA DURING TREATMENT PERIOD |
| title_full | GENE EXPRESSION DYNAMICS IN PATIENTS WITH SEVERE THERAPY-RESISTANT ASTHMA DURING TREATMENT PERIOD |
| title_fullStr | GENE EXPRESSION DYNAMICS IN PATIENTS WITH SEVERE THERAPY-RESISTANT ASTHMA DURING TREATMENT PERIOD |
| title_full_unstemmed | GENE EXPRESSION DYNAMICS IN PATIENTS WITH SEVERE THERAPY-RESISTANT ASTHMA DURING TREATMENT PERIOD |
| title_short | GENE EXPRESSION DYNAMICS IN PATIENTS WITH SEVERE THERAPY-RESISTANT ASTHMA DURING TREATMENT PERIOD |
| title_sort | gene expression dynamics in patients with severe therapy resistant asthma during treatment period |
| topic | bronchial asthma therapy severe bronchial asthma therapy resistance molecular mechanisms |
| url | https://bulletin.ssmu.ru/jour/article/view/16 |
| work_keys_str_mv | AT yeskulikov geneexpressiondynamicsinpatientswithseveretherapyresistantasthmaduringtreatmentperiod AT lmogorodova geneexpressiondynamicsinpatientswithseveretherapyresistantasthmaduringtreatmentperiod AT mbfreidin geneexpressiondynamicsinpatientswithseveretherapyresistantasthmaduringtreatmentperiod AT ivsaltikova geneexpressiondynamicsinpatientswithseveretherapyresistantasthmaduringtreatmentperiod AT iadeyev geneexpressiondynamicsinpatientswithseveretherapyresistantasthmaduringtreatmentperiod AT paselivanova geneexpressiondynamicsinpatientswithseveretherapyresistantasthmaduringtreatmentperiod |