Rapid Progression of Red Itchy Rash, Diagnostic Dilemma
Cutaneous T-cell lymphoma (CTCL) is an uncommon type of cancer that begins in white blood cells called T lymphocytes (T cells). Normally, T cells help body's immune system to fight off infection but, in CTCL, these cells develop abnormalities that make them attack the skin. It comprises hetero...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON)
2023-03-01
|
| Series: | Nepal Journal of Dermatology, Venereology & Leprology |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/NJDVL/article/view/52161 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849227414970826752 |
|---|---|
| author | Uma Keyal Gopi Aryal Sanju Babu Shrestha Anil Kumar Bhatta |
| author_facet | Uma Keyal Gopi Aryal Sanju Babu Shrestha Anil Kumar Bhatta |
| author_sort | Uma Keyal |
| collection | DOAJ |
| description |
Cutaneous T-cell lymphoma (CTCL) is an uncommon type of cancer that begins in white blood cells called T lymphocytes (T cells). Normally, T cells help body's immune system to fight off infection but, in CTCL, these cells develop abnormalities that make them attack the skin. It comprises heterogeneous group of skin neoplasms, the most common being mycosis fungoides (MF). Skin lesions are classified into patches, plaques, and tumor stage. Extra skin manifestations like enlarged lymph nodes are usually seen in plaques or tumor stage, when there are thick lesions on skin. It is usually a slow growing cancer that develops over many years. Herein, we present an 83-year female patient who suddenly developed extremely itchy patches on abdomen, which had spread to involve the entire trunk and all four limbs in about 10 days’ time. She already had lymphadenopathy and splenomegaly at the time of presentation. Skin biopsy and immunohistochemistry revealed CD4+ T cells CTCL. Moreover, bone marrow was hypercellular for age with 12% atypical lymphocytes. It is very unusual for CTCL to involve bone marrow at patch stage with no any plaques or nodules on the skin. Also, the sudden onset of skin lesions and its rapid progression with probably, the involvement of lymph nodes and spleen warrant further studies to guide diagnostic approaches and treatment recommendations for CTCL
|
| format | Article |
| id | doaj-art-218e14439824472499a11c3fbd124d2c |
| institution | Kabale University |
| issn | 2091-0231 2091-167X |
| language | English |
| publishDate | 2023-03-01 |
| publisher | Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON) |
| record_format | Article |
| series | Nepal Journal of Dermatology, Venereology & Leprology |
| spelling | doaj-art-218e14439824472499a11c3fbd124d2c2025-08-23T10:03:45ZengSociety of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON)Nepal Journal of Dermatology, Venereology & Leprology2091-02312091-167X2023-03-0121110.3126/njdvl.v21i1.52161Rapid Progression of Red Itchy Rash, Diagnostic DilemmaUma Keyal0Gopi Aryal1Sanju Babu Shrestha2Anil Kumar Bhatta3Department of Dermatology, Nepal Mediciti Hospital, Lalitpur, Kathmandu, NepalDepartment of Pathology, Nepal Mediciti Hospital, Lalitpur, Kathmandu, NepalDepartment of Dermatology, Nepal Mediciti Hospital, Lalitpur, Kathmandu, NepalDerm Dynamics Skin Hair and Laser Clinic, Kumaripati, Lalitpur, Kathmandu, Nepal Cutaneous T-cell lymphoma (CTCL) is an uncommon type of cancer that begins in white blood cells called T lymphocytes (T cells). Normally, T cells help body's immune system to fight off infection but, in CTCL, these cells develop abnormalities that make them attack the skin. It comprises heterogeneous group of skin neoplasms, the most common being mycosis fungoides (MF). Skin lesions are classified into patches, plaques, and tumor stage. Extra skin manifestations like enlarged lymph nodes are usually seen in plaques or tumor stage, when there are thick lesions on skin. It is usually a slow growing cancer that develops over many years. Herein, we present an 83-year female patient who suddenly developed extremely itchy patches on abdomen, which had spread to involve the entire trunk and all four limbs in about 10 days’ time. She already had lymphadenopathy and splenomegaly at the time of presentation. Skin biopsy and immunohistochemistry revealed CD4+ T cells CTCL. Moreover, bone marrow was hypercellular for age with 12% atypical lymphocytes. It is very unusual for CTCL to involve bone marrow at patch stage with no any plaques or nodules on the skin. Also, the sudden onset of skin lesions and its rapid progression with probably, the involvement of lymph nodes and spleen warrant further studies to guide diagnostic approaches and treatment recommendations for CTCL https://www.nepjol.info/index.php/NJDVL/article/view/52161Cutaneous T cell lymphoma, mycosis fungoides, skin neoplasm, T lymphocytes. |
| spellingShingle | Uma Keyal Gopi Aryal Sanju Babu Shrestha Anil Kumar Bhatta Rapid Progression of Red Itchy Rash, Diagnostic Dilemma Nepal Journal of Dermatology, Venereology & Leprology Cutaneous T cell lymphoma, mycosis fungoides, skin neoplasm, T lymphocytes. |
| title | Rapid Progression of Red Itchy Rash, Diagnostic Dilemma |
| title_full | Rapid Progression of Red Itchy Rash, Diagnostic Dilemma |
| title_fullStr | Rapid Progression of Red Itchy Rash, Diagnostic Dilemma |
| title_full_unstemmed | Rapid Progression of Red Itchy Rash, Diagnostic Dilemma |
| title_short | Rapid Progression of Red Itchy Rash, Diagnostic Dilemma |
| title_sort | rapid progression of red itchy rash diagnostic dilemma |
| topic | Cutaneous T cell lymphoma, mycosis fungoides, skin neoplasm, T lymphocytes. |
| url | https://www.nepjol.info/index.php/NJDVL/article/view/52161 |
| work_keys_str_mv | AT umakeyal rapidprogressionofreditchyrashdiagnosticdilemma AT gopiaryal rapidprogressionofreditchyrashdiagnosticdilemma AT sanjubabushrestha rapidprogressionofreditchyrashdiagnosticdilemma AT anilkumarbhatta rapidprogressionofreditchyrashdiagnosticdilemma |