The Role of Extracellular Adenosine Generation in the Development of Autoimmune Diseases
Adenosine (ADO) is an immunosuppressive molecule, which suppresses the immune responses by interacting with specific receptors expressed by immune effector cells. ADO is produced from ATP through the enzymatic activities of CD39 and CD73. Alternatively, ADO can be generated starting from NAD+, which...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/7019398 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849307673974013952 |
|---|---|
| author | F. Morandi A. L. Horenstein R. Rizzo F. Malavasi |
| author_facet | F. Morandi A. L. Horenstein R. Rizzo F. Malavasi |
| author_sort | F. Morandi |
| collection | DOAJ |
| description | Adenosine (ADO) is an immunosuppressive molecule, which suppresses the immune responses by interacting with specific receptors expressed by immune effector cells. ADO is produced from ATP through the enzymatic activities of CD39 and CD73. Alternatively, ADO can be generated starting from NAD+, which is metabolized by the concerted action of CD38, CD203a/PC-1, and CD73. The role of ADO in immunity has been characterized in the last years in physiology and in pathological settings. This review examines a panel of reports focused on the functions of ADO in the context of human autoimmune/inflammatory diseases and the selected animal models. The final aim is to consider the role of adenosinergic ectoenzymes and ADO receptors as novel therapeutic targets for selected diseases. |
| format | Article |
| id | doaj-art-218dabc33e3147e5ad01916a7122e12e |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-218dabc33e3147e5ad01916a7122e12e2025-08-20T03:54:42ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/70193987019398The Role of Extracellular Adenosine Generation in the Development of Autoimmune DiseasesF. Morandi0A. L. Horenstein1R. Rizzo2F. Malavasi3Stem Cell Laboratory and Cell Therapy Center, Istituto Giannina Gaslini, 16148 Genova, ItalyDepartment of Medical Sciences, Laboratory of Immunogenetics, University of Torino, 10126 Torino, ItalyDepartment of Medical Sciences, Section of Microbiology, University of Ferrara, 44121 Ferrara, ItalyDepartment of Medical Sciences, Laboratory of Immunogenetics, University of Torino, 10126 Torino, ItalyAdenosine (ADO) is an immunosuppressive molecule, which suppresses the immune responses by interacting with specific receptors expressed by immune effector cells. ADO is produced from ATP through the enzymatic activities of CD39 and CD73. Alternatively, ADO can be generated starting from NAD+, which is metabolized by the concerted action of CD38, CD203a/PC-1, and CD73. The role of ADO in immunity has been characterized in the last years in physiology and in pathological settings. This review examines a panel of reports focused on the functions of ADO in the context of human autoimmune/inflammatory diseases and the selected animal models. The final aim is to consider the role of adenosinergic ectoenzymes and ADO receptors as novel therapeutic targets for selected diseases.http://dx.doi.org/10.1155/2018/7019398 |
| spellingShingle | F. Morandi A. L. Horenstein R. Rizzo F. Malavasi The Role of Extracellular Adenosine Generation in the Development of Autoimmune Diseases Mediators of Inflammation |
| title | The Role of Extracellular Adenosine Generation in the Development of Autoimmune Diseases |
| title_full | The Role of Extracellular Adenosine Generation in the Development of Autoimmune Diseases |
| title_fullStr | The Role of Extracellular Adenosine Generation in the Development of Autoimmune Diseases |
| title_full_unstemmed | The Role of Extracellular Adenosine Generation in the Development of Autoimmune Diseases |
| title_short | The Role of Extracellular Adenosine Generation in the Development of Autoimmune Diseases |
| title_sort | role of extracellular adenosine generation in the development of autoimmune diseases |
| url | http://dx.doi.org/10.1155/2018/7019398 |
| work_keys_str_mv | AT fmorandi theroleofextracellularadenosinegenerationinthedevelopmentofautoimmunediseases AT alhorenstein theroleofextracellularadenosinegenerationinthedevelopmentofautoimmunediseases AT rrizzo theroleofextracellularadenosinegenerationinthedevelopmentofautoimmunediseases AT fmalavasi theroleofextracellularadenosinegenerationinthedevelopmentofautoimmunediseases AT fmorandi roleofextracellularadenosinegenerationinthedevelopmentofautoimmunediseases AT alhorenstein roleofextracellularadenosinegenerationinthedevelopmentofautoimmunediseases AT rrizzo roleofextracellularadenosinegenerationinthedevelopmentofautoimmunediseases AT fmalavasi roleofextracellularadenosinegenerationinthedevelopmentofautoimmunediseases |