Modifying the platform-mediated avoidance task: A new protocol to study active avoidance within a social context in rats.
The platform-mediated active avoidance (PMA) task has been used to study the behavioral and neural mechanisms of a decision-based form of active avoidance. Across 10 days of PMA conditioning, rats learn to avoid a tone-signaled footshock by moving to a safe platform at the cost of forfeiting sucrose...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0321776 |
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| author | Cassandra Kramer Shannon Ruble Troy D Fort Lexe West Maria M Diehl |
| author_facet | Cassandra Kramer Shannon Ruble Troy D Fort Lexe West Maria M Diehl |
| author_sort | Cassandra Kramer |
| collection | DOAJ |
| description | The platform-mediated active avoidance (PMA) task has been used to study the behavioral and neural mechanisms of a decision-based form of active avoidance. Across 10 days of PMA conditioning, rats learn to avoid a tone-signaled footshock by moving to a safe platform at the cost of forfeiting sucrose reward. Prior studies utilizing the PMA task involved rats learning to avoid alone in a solitary context, but we have recently modified the task to include a social context to determine how social cues may influence PMA acquisition. Additionally, we report novel measures of social interaction that occur during Social Partner PMA conditioning. This protocol provides a detailed methodology for studying active avoidance within solitary and social contexts, as well as key considerations when employing the PMA task. |
| format | Article |
| id | doaj-art-218c8a86c42443a59430093d775badea |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-218c8a86c42443a59430093d775badea2025-08-20T03:11:52ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01204e032177610.1371/journal.pone.0321776Modifying the platform-mediated avoidance task: A new protocol to study active avoidance within a social context in rats.Cassandra KramerShannon RubleTroy D FortLexe WestMaria M DiehlThe platform-mediated active avoidance (PMA) task has been used to study the behavioral and neural mechanisms of a decision-based form of active avoidance. Across 10 days of PMA conditioning, rats learn to avoid a tone-signaled footshock by moving to a safe platform at the cost of forfeiting sucrose reward. Prior studies utilizing the PMA task involved rats learning to avoid alone in a solitary context, but we have recently modified the task to include a social context to determine how social cues may influence PMA acquisition. Additionally, we report novel measures of social interaction that occur during Social Partner PMA conditioning. This protocol provides a detailed methodology for studying active avoidance within solitary and social contexts, as well as key considerations when employing the PMA task.https://doi.org/10.1371/journal.pone.0321776 |
| spellingShingle | Cassandra Kramer Shannon Ruble Troy D Fort Lexe West Maria M Diehl Modifying the platform-mediated avoidance task: A new protocol to study active avoidance within a social context in rats. PLoS ONE |
| title | Modifying the platform-mediated avoidance task: A new protocol to study active avoidance within a social context in rats. |
| title_full | Modifying the platform-mediated avoidance task: A new protocol to study active avoidance within a social context in rats. |
| title_fullStr | Modifying the platform-mediated avoidance task: A new protocol to study active avoidance within a social context in rats. |
| title_full_unstemmed | Modifying the platform-mediated avoidance task: A new protocol to study active avoidance within a social context in rats. |
| title_short | Modifying the platform-mediated avoidance task: A new protocol to study active avoidance within a social context in rats. |
| title_sort | modifying the platform mediated avoidance task a new protocol to study active avoidance within a social context in rats |
| url | https://doi.org/10.1371/journal.pone.0321776 |
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