Cell-membrane targeting sonodynamic therapy combination with FSP1 inhibition for ferroptosis-boosted immunotherapy
Cell membrane targeting sonodynamic therapy could induce the accumulation of lipid peroxidation (LPO), drive ferroptosis, and further enhances immunogenic cell death (ICD) effects. However, ferroptosis is restrained by the ferroptosis suppressor protein 1 (FSP1) at the plasma membrane, which can cat...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
|
| Series: | Materials Today Bio |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S259000642400468X |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841533287657373696 |
|---|---|
| author | Jian Chen Qiyu Zhan Lie Li Simin Xi Longmei Cai Ruiyuan Liu Lujia Chen |
| author_facet | Jian Chen Qiyu Zhan Lie Li Simin Xi Longmei Cai Ruiyuan Liu Lujia Chen |
| author_sort | Jian Chen |
| collection | DOAJ |
| description | Cell membrane targeting sonodynamic therapy could induce the accumulation of lipid peroxidation (LPO), drive ferroptosis, and further enhances immunogenic cell death (ICD) effects. However, ferroptosis is restrained by the ferroptosis suppressor protein 1 (FSP1) at the plasma membrane, which can catalyze the regeneration of ubiquinone (CoQ10) by using NAD(P)H to suppress the LPO accumulation. This work describes the construction of US-active nanoparticles (TiF NPs), which combinate cell-membrane targeting sonosensitizer TBT-CQi with FSP1 inhibitor (iFSP1), facilitating cell-membrane targeting sonodynamic-triggered ferroptosis. TiF NPs could induce a sonodynamic effect, which promotes lipid peroxidation and drives apoptosis. Furthermore, TiF NPs could suppress FSP1, induce CoQ10 depletion, down-regulate the NADH, enhance LPO accumulation, and finally induce ferroptosis. In vitro results demonstrated that synergetic cell membrane targeting SDT/FSP1 inhibition triggered immunogenic cell death (ICD). Moreover, the as-synthesized TiF NPs-mediated cell membrane targeting SDT/FSP1 inhibition thoroughly inhibited the tumor growth and simultaneously activated antitumor immunity to suppress lung metastasis. This work represents a promising tumor therapeutic strategy combining cell membrane targeting SDT and FSP1 inhibition, potentially inspiring further research in developing logical and effective cancer therapies based on synergistic SDT/ferroptosis. |
| format | Article |
| id | doaj-art-21891999ea9648999ded70ac9831a88c |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-21891999ea9648999ded70ac9831a88c2025-01-17T04:52:07ZengElsevierMaterials Today Bio2590-00642025-02-0130101407Cell-membrane targeting sonodynamic therapy combination with FSP1 inhibition for ferroptosis-boosted immunotherapyJian Chen0Qiyu Zhan1Lie Li2Simin Xi3Longmei Cai4Ruiyuan Liu5Lujia Chen6Biomaterials Research Center, School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, PR ChinaBiomaterials Research Center, School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, PR ChinaBiomaterials Research Center, School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, PR ChinaBiomaterials Research Center, School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, PR ChinaDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, PR China; Corresponding author.Biomaterials Research Center, School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, PR China; Corresponding author.Breast Center, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, PR China; Corresponding author.Cell membrane targeting sonodynamic therapy could induce the accumulation of lipid peroxidation (LPO), drive ferroptosis, and further enhances immunogenic cell death (ICD) effects. However, ferroptosis is restrained by the ferroptosis suppressor protein 1 (FSP1) at the plasma membrane, which can catalyze the regeneration of ubiquinone (CoQ10) by using NAD(P)H to suppress the LPO accumulation. This work describes the construction of US-active nanoparticles (TiF NPs), which combinate cell-membrane targeting sonosensitizer TBT-CQi with FSP1 inhibitor (iFSP1), facilitating cell-membrane targeting sonodynamic-triggered ferroptosis. TiF NPs could induce a sonodynamic effect, which promotes lipid peroxidation and drives apoptosis. Furthermore, TiF NPs could suppress FSP1, induce CoQ10 depletion, down-regulate the NADH, enhance LPO accumulation, and finally induce ferroptosis. In vitro results demonstrated that synergetic cell membrane targeting SDT/FSP1 inhibition triggered immunogenic cell death (ICD). Moreover, the as-synthesized TiF NPs-mediated cell membrane targeting SDT/FSP1 inhibition thoroughly inhibited the tumor growth and simultaneously activated antitumor immunity to suppress lung metastasis. This work represents a promising tumor therapeutic strategy combining cell membrane targeting SDT and FSP1 inhibition, potentially inspiring further research in developing logical and effective cancer therapies based on synergistic SDT/ferroptosis.http://www.sciencedirect.com/science/article/pii/S259000642400468XCell membrane targetingSonodynamic therapyferroptosisFSP1 inhibitionImmunogenic cell death |
| spellingShingle | Jian Chen Qiyu Zhan Lie Li Simin Xi Longmei Cai Ruiyuan Liu Lujia Chen Cell-membrane targeting sonodynamic therapy combination with FSP1 inhibition for ferroptosis-boosted immunotherapy Materials Today Bio Cell membrane targeting Sonodynamic therapy ferroptosis FSP1 inhibition Immunogenic cell death |
| title | Cell-membrane targeting sonodynamic therapy combination with FSP1 inhibition for ferroptosis-boosted immunotherapy |
| title_full | Cell-membrane targeting sonodynamic therapy combination with FSP1 inhibition for ferroptosis-boosted immunotherapy |
| title_fullStr | Cell-membrane targeting sonodynamic therapy combination with FSP1 inhibition for ferroptosis-boosted immunotherapy |
| title_full_unstemmed | Cell-membrane targeting sonodynamic therapy combination with FSP1 inhibition for ferroptosis-boosted immunotherapy |
| title_short | Cell-membrane targeting sonodynamic therapy combination with FSP1 inhibition for ferroptosis-boosted immunotherapy |
| title_sort | cell membrane targeting sonodynamic therapy combination with fsp1 inhibition for ferroptosis boosted immunotherapy |
| topic | Cell membrane targeting Sonodynamic therapy ferroptosis FSP1 inhibition Immunogenic cell death |
| url | http://www.sciencedirect.com/science/article/pii/S259000642400468X |
| work_keys_str_mv | AT jianchen cellmembranetargetingsonodynamictherapycombinationwithfsp1inhibitionforferroptosisboostedimmunotherapy AT qiyuzhan cellmembranetargetingsonodynamictherapycombinationwithfsp1inhibitionforferroptosisboostedimmunotherapy AT lieli cellmembranetargetingsonodynamictherapycombinationwithfsp1inhibitionforferroptosisboostedimmunotherapy AT siminxi cellmembranetargetingsonodynamictherapycombinationwithfsp1inhibitionforferroptosisboostedimmunotherapy AT longmeicai cellmembranetargetingsonodynamictherapycombinationwithfsp1inhibitionforferroptosisboostedimmunotherapy AT ruiyuanliu cellmembranetargetingsonodynamictherapycombinationwithfsp1inhibitionforferroptosisboostedimmunotherapy AT lujiachen cellmembranetargetingsonodynamictherapycombinationwithfsp1inhibitionforferroptosisboostedimmunotherapy |