Lumbar Puncture Alleviates Chorea in a Patient with Huntington’s Disease and Normal Pressure Hydrocephalus
A 44-year-old African-American male was admitted to our hospital after a suicide attempt. He had depression, poor cognitive function, choreiform movements, difficulty pronouncing words, and difficulty walking. His symptoms had worsened markedly over several months. Chorea lead to genetic testing tha...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.3233/BEN-2009-0239 |
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| author | Peyman Shirani Alicia R. Salamone Elham Lahijani Michele K. York Paul E. Schulz |
| author_facet | Peyman Shirani Alicia R. Salamone Elham Lahijani Michele K. York Paul E. Schulz |
| author_sort | Peyman Shirani |
| collection | DOAJ |
| description | A 44-year-old African-American male was admitted to our hospital after a suicide attempt. He had depression, poor cognitive function, choreiform movements, difficulty pronouncing words, and difficulty walking. His symptoms had worsened markedly over several months. Chorea lead to genetic testing that confirmed a diagnosis of Huntington Disease (HD). A CT scan of the head showed wider ventricles than is typical of HD. The head CT and gait change suggested normal pressure hydrocephalus (NPH). Lumbar puncture (LP) led to improved neuropsychologic test scores and walking thereby supporting the diagnosis of NPH. Surprisingly, the LP also led to an 80% improvement of chorea. There are two other reports of an association between HD and NPH. NPH should be considered in HD patients with atypical symptoms, such as the inability to walk or rapid progression, as its treatment may lead to improved cognition, gait, and chorea. |
| format | Article |
| id | doaj-art-21867d1e889f4e6786b28bc1bd0d7af7 |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-21867d1e889f4e6786b28bc1bd0d7af72025-08-20T03:54:42ZengWileyBehavioural Neurology0953-41801875-85842009-01-01213-419319510.3233/BEN-2009-0239Lumbar Puncture Alleviates Chorea in a Patient with Huntington’s Disease and Normal Pressure HydrocephalusPeyman Shirani0Alicia R. Salamone1Elham Lahijani2Michele K. York3Paul E. Schulz4Department of Neurology, Baylor College of Medicine, Houston, TX, USADepartment of Neurology, Baylor College of Medicine, Houston, TX, USAThe Methodist Hospital, Houston, TX, USADepartment of Neurology, Baylor College of Medicine, Houston, TX, USADepartment of Neurology, Baylor College of Medicine, Houston, TX, USAA 44-year-old African-American male was admitted to our hospital after a suicide attempt. He had depression, poor cognitive function, choreiform movements, difficulty pronouncing words, and difficulty walking. His symptoms had worsened markedly over several months. Chorea lead to genetic testing that confirmed a diagnosis of Huntington Disease (HD). A CT scan of the head showed wider ventricles than is typical of HD. The head CT and gait change suggested normal pressure hydrocephalus (NPH). Lumbar puncture (LP) led to improved neuropsychologic test scores and walking thereby supporting the diagnosis of NPH. Surprisingly, the LP also led to an 80% improvement of chorea. There are two other reports of an association between HD and NPH. NPH should be considered in HD patients with atypical symptoms, such as the inability to walk or rapid progression, as its treatment may lead to improved cognition, gait, and chorea.http://dx.doi.org/10.3233/BEN-2009-0239 |
| spellingShingle | Peyman Shirani Alicia R. Salamone Elham Lahijani Michele K. York Paul E. Schulz Lumbar Puncture Alleviates Chorea in a Patient with Huntington’s Disease and Normal Pressure Hydrocephalus Behavioural Neurology |
| title | Lumbar Puncture Alleviates Chorea in a Patient with Huntington’s Disease and Normal Pressure Hydrocephalus |
| title_full | Lumbar Puncture Alleviates Chorea in a Patient with Huntington’s Disease and Normal Pressure Hydrocephalus |
| title_fullStr | Lumbar Puncture Alleviates Chorea in a Patient with Huntington’s Disease and Normal Pressure Hydrocephalus |
| title_full_unstemmed | Lumbar Puncture Alleviates Chorea in a Patient with Huntington’s Disease and Normal Pressure Hydrocephalus |
| title_short | Lumbar Puncture Alleviates Chorea in a Patient with Huntington’s Disease and Normal Pressure Hydrocephalus |
| title_sort | lumbar puncture alleviates chorea in a patient with huntington s disease and normal pressure hydrocephalus |
| url | http://dx.doi.org/10.3233/BEN-2009-0239 |
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