High normal blood pressure and left ventricular structural and functional disorders in young adults
Aim. To evaluate the association of a high normal blood pressure (BP) with the risk of early hypertension-mediated organ damage (HMOD) in young adults.Material and methods. Medical screening of population aged 18-45 years (n=987) revealed that in 173 persons, office BP corresponded to a high normal...
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«SILICEA-POLIGRAF» LLC
2022-09-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/3282 |
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| author | E. K. Shavarova I. A. Khomova Zh. D. Kobalava E. I. Kirpichnikova N. E. Ezhova E. I. Bazdyreva |
| author_facet | E. K. Shavarova I. A. Khomova Zh. D. Kobalava E. I. Kirpichnikova N. E. Ezhova E. I. Bazdyreva |
| author_sort | E. K. Shavarova |
| collection | DOAJ |
| description | Aim. To evaluate the association of a high normal blood pressure (BP) with the risk of early hypertension-mediated organ damage (HMOD) in young adults.Material and methods. Medical screening of population aged 18-45 years (n=987) revealed that in 173 persons, office BP corresponded to a high normal level or hypertension (HTN). Echocardiography (GE Healthcare Vivid 9, using EchoPAC Software) was performed when HTN was confirmed by office BP measurement and/or according to 24-hour ambulatory BP monitoring (ABPM) (n=127). In addition, creatinine and albumin-to-creatinine ratio in spot urine were measured.Results. The median age was 23 [21; 25] years. The median systolic (SBP) and diastolic BP (DBP) was 129 [121; 137] and 75±12 mm Hg, respectively. The detection rate of LV geometry abnormalities was 3,3 times higher in the high normal BP group [95% CI, 1,06-6,28, p=0,02], and 10,7 times higher in the HTN group [95% CI, 2,32-16,49, p=0,04] compared with the optimal+normal BP group. In a multivariate analysis, the independence of associations with the LV mass index (LVMI) was confirmed only for the mean nighttime DBP, left atrial volume index, and the ratio of LV peak early diastolic velocity to the average septal and lateral peak early diastolic mitral annular velocity.Conclusion. In young people, the prevalance of HMOD is comparable in the groups with high normal BP and HTN, while significant differences were found between the group with optimal+normal BP levels and patients with HTN and high normal BP. An independent association of elevated LVMI with mean nighttime DBP was found. |
| format | Article |
| id | doaj-art-216d35b89b5e40bd879dfa28fb764877 |
| institution | DOAJ |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2022-09-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-216d35b89b5e40bd879dfa28fb7648772025-08-20T03:18:46Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252022-09-0121810.15829/1728-8800-2022-32822517High normal blood pressure and left ventricular structural and functional disorders in young adultsE. K. Shavarova0I. A. Khomova1Zh. D. Kobalava2E. I. Kirpichnikova3N. E. Ezhova4E. I. Bazdyreva5Peoples’ Friendship University of Russia; V. V. Vinogradov City Clinical HospitalPeoples’ Friendship University of RussiaPeoples’ Friendship University of RussiaPirogov Russian National Research Medical UniversityPeoples’ Friendship University of Russia; V. V. Vinogradov City Clinical HospitalV. V. Vinogradov City Clinical HospitalAim. To evaluate the association of a high normal blood pressure (BP) with the risk of early hypertension-mediated organ damage (HMOD) in young adults.Material and methods. Medical screening of population aged 18-45 years (n=987) revealed that in 173 persons, office BP corresponded to a high normal level or hypertension (HTN). Echocardiography (GE Healthcare Vivid 9, using EchoPAC Software) was performed when HTN was confirmed by office BP measurement and/or according to 24-hour ambulatory BP monitoring (ABPM) (n=127). In addition, creatinine and albumin-to-creatinine ratio in spot urine were measured.Results. The median age was 23 [21; 25] years. The median systolic (SBP) and diastolic BP (DBP) was 129 [121; 137] and 75±12 mm Hg, respectively. The detection rate of LV geometry abnormalities was 3,3 times higher in the high normal BP group [95% CI, 1,06-6,28, p=0,02], and 10,7 times higher in the HTN group [95% CI, 2,32-16,49, p=0,04] compared with the optimal+normal BP group. In a multivariate analysis, the independence of associations with the LV mass index (LVMI) was confirmed only for the mean nighttime DBP, left atrial volume index, and the ratio of LV peak early diastolic velocity to the average septal and lateral peak early diastolic mitral annular velocity.Conclusion. In young people, the prevalance of HMOD is comparable in the groups with high normal BP and HTN, while significant differences were found between the group with optimal+normal BP levels and patients with HTN and high normal BP. An independent association of elevated LVMI with mean nighttime DBP was found.https://cardiovascular.elpub.ru/jour/article/view/3282hypertensionhypertension-mediated organ damageyoung adults |
| spellingShingle | E. K. Shavarova I. A. Khomova Zh. D. Kobalava E. I. Kirpichnikova N. E. Ezhova E. I. Bazdyreva High normal blood pressure and left ventricular structural and functional disorders in young adults Кардиоваскулярная терапия и профилактика hypertension hypertension-mediated organ damage young adults |
| title | High normal blood pressure and left ventricular structural and functional disorders in young adults |
| title_full | High normal blood pressure and left ventricular structural and functional disorders in young adults |
| title_fullStr | High normal blood pressure and left ventricular structural and functional disorders in young adults |
| title_full_unstemmed | High normal blood pressure and left ventricular structural and functional disorders in young adults |
| title_short | High normal blood pressure and left ventricular structural and functional disorders in young adults |
| title_sort | high normal blood pressure and left ventricular structural and functional disorders in young adults |
| topic | hypertension hypertension-mediated organ damage young adults |
| url | https://cardiovascular.elpub.ru/jour/article/view/3282 |
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