The cerebral metabolic mechanism of group computer magnanimous therapy based on magnetic resonance spectroscopy: effects on improving magnanimous-enterprising levels of lung cancer patients
IntroductionThis study aims to evaluate the effects of group computer magnanimous therapy (GCMT) on magnanimous-enterprising levels and brain metabolic changes in patients with advanced lung cancer.MethodsIn this multicenter, randomized controlled trial, 47 participants diagnosed with advanced stage...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1397375/full |
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| author | Qianyu Liu Qihui Ma Qingfeng Sun Xuewei Huang Xuewei Huang |
| author_facet | Qianyu Liu Qihui Ma Qingfeng Sun Xuewei Huang Xuewei Huang |
| author_sort | Qianyu Liu |
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| description | IntroductionThis study aims to evaluate the effects of group computer magnanimous therapy (GCMT) on magnanimous-enterprising levels and brain metabolic changes in patients with advanced lung cancer.MethodsIn this multicenter, randomized controlled trial, 47 participants diagnosed with advanced stage (III or IV) lung cancer were randomly assigned to either the GCMT group (GCMTG, n = 31) or the control group (CTRLG, n = 16). The GCMTG received routine oncotherapy and care along with eight sessions of GCMT over 2 weeks, while the CTRLG received only oncotherapy and routine care. Psychological and brain metabolic changes were assessed using the Enterprising and Magnanimous Questionnaire (EMQ) and proton magnetic resonance spectroscopy (1H-MRS).ResultsAfter 2 weeks, the GCMTG showed significant improvements in the EMQ “total score” and “enterprising” dimensions compared to baseline (p < 0.05), while the CTRLG showed no significant changes. Significant increases in NAA/Cr levels were observed in the right amygdala, and significant decreases in mI/Cr levels were observed in the right cingulate gyrus in the GCMTG. Pearson correlation analysis indicated that changes in Cho/Cr levels in the left amygdala and Glx/Cr levels in the left hippocampus were significantly correlated with improvements in the enterprising dimension.ConclusionsGCMT significantly enhanced enterprising attitudes and induced beneficial changes in brain metabolites among patients with advanced lung cancer. Further research with larger sample sizes is warranted to confirm these results and explore the long-term effects of GCMT.Clinical trial registrationhttps://www.chictr.org.cn/showproj.html?proj=129557, identifier ChiCTR2100053015. |
| format | Article |
| id | doaj-art-216c8e283cdc485b9eb5cfadd0c47956 |
| institution | OA Journals |
| issn | 1664-0640 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Psychiatry |
| spelling | doaj-art-216c8e283cdc485b9eb5cfadd0c479562025-08-20T02:38:25ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402024-12-011510.3389/fpsyt.2024.13973751397375The cerebral metabolic mechanism of group computer magnanimous therapy based on magnetic resonance spectroscopy: effects on improving magnanimous-enterprising levels of lung cancer patientsQianyu Liu0Qihui Ma1Qingfeng Sun2Xuewei Huang3Xuewei Huang4Psychological Clinic, Guangxi Chest Hospital, Liuzhou, Guangxi, ChinaMedical Department, Huizhou Central People’s Hospital, Huizhou, Guangdong, ChinaDepartment of Pulmonary Medicine, Guangxi Chest Hospital, Liuzhou, Guangxi, ChinaPsychological Clinic, Guangxi Chest Hospital, Liuzhou, Guangxi, ChinaDepartment of Psychiatry & Medical Psychology, The First Affiliated Hospital, College of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong, ChinaIntroductionThis study aims to evaluate the effects of group computer magnanimous therapy (GCMT) on magnanimous-enterprising levels and brain metabolic changes in patients with advanced lung cancer.MethodsIn this multicenter, randomized controlled trial, 47 participants diagnosed with advanced stage (III or IV) lung cancer were randomly assigned to either the GCMT group (GCMTG, n = 31) or the control group (CTRLG, n = 16). The GCMTG received routine oncotherapy and care along with eight sessions of GCMT over 2 weeks, while the CTRLG received only oncotherapy and routine care. Psychological and brain metabolic changes were assessed using the Enterprising and Magnanimous Questionnaire (EMQ) and proton magnetic resonance spectroscopy (1H-MRS).ResultsAfter 2 weeks, the GCMTG showed significant improvements in the EMQ “total score” and “enterprising” dimensions compared to baseline (p < 0.05), while the CTRLG showed no significant changes. Significant increases in NAA/Cr levels were observed in the right amygdala, and significant decreases in mI/Cr levels were observed in the right cingulate gyrus in the GCMTG. Pearson correlation analysis indicated that changes in Cho/Cr levels in the left amygdala and Glx/Cr levels in the left hippocampus were significantly correlated with improvements in the enterprising dimension.ConclusionsGCMT significantly enhanced enterprising attitudes and induced beneficial changes in brain metabolites among patients with advanced lung cancer. Further research with larger sample sizes is warranted to confirm these results and explore the long-term effects of GCMT.Clinical trial registrationhttps://www.chictr.org.cn/showproj.html?proj=129557, identifier ChiCTR2100053015.https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1397375/fullgroup computer magnanimous therapymagnanimous-enterprising levelbrain metabolismlung cancerpsychosomatic effects |
| spellingShingle | Qianyu Liu Qihui Ma Qingfeng Sun Xuewei Huang Xuewei Huang The cerebral metabolic mechanism of group computer magnanimous therapy based on magnetic resonance spectroscopy: effects on improving magnanimous-enterprising levels of lung cancer patients Frontiers in Psychiatry group computer magnanimous therapy magnanimous-enterprising level brain metabolism lung cancer psychosomatic effects |
| title | The cerebral metabolic mechanism of group computer magnanimous therapy based on magnetic resonance spectroscopy: effects on improving magnanimous-enterprising levels of lung cancer patients |
| title_full | The cerebral metabolic mechanism of group computer magnanimous therapy based on magnetic resonance spectroscopy: effects on improving magnanimous-enterprising levels of lung cancer patients |
| title_fullStr | The cerebral metabolic mechanism of group computer magnanimous therapy based on magnetic resonance spectroscopy: effects on improving magnanimous-enterprising levels of lung cancer patients |
| title_full_unstemmed | The cerebral metabolic mechanism of group computer magnanimous therapy based on magnetic resonance spectroscopy: effects on improving magnanimous-enterprising levels of lung cancer patients |
| title_short | The cerebral metabolic mechanism of group computer magnanimous therapy based on magnetic resonance spectroscopy: effects on improving magnanimous-enterprising levels of lung cancer patients |
| title_sort | cerebral metabolic mechanism of group computer magnanimous therapy based on magnetic resonance spectroscopy effects on improving magnanimous enterprising levels of lung cancer patients |
| topic | group computer magnanimous therapy magnanimous-enterprising level brain metabolism lung cancer psychosomatic effects |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1397375/full |
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