Three-dimensional bioprinted in vitro glioma tumor constructs for synchrotron microbeam radiotherapy dosimetry and biological study using gelatin methacryloyl hydrogel

Three-dimensional bioprinted in vitro glioma tumor constructs for synchrotron microbeam radiotherapy dosimetry and biological study using gelatin methacryloyl hydrogel

Abstract Synchrotron microbeam radiotherapy (MRT) is an innovative cancer treatment that uses micron-sized of ultra-high dose rate spatially fractionated X-rays to effectively control cancer growth while reducing the damage to surrounding healthy tissue. However, the current pre-clinical experiments...

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Bibliographic Details
Main Authors: John Paul O. Bustillo, Elette E.M. Engels, Vincent de Rover, Kiarn Roughley, Julia Rebecca D. Posadas, Elrick T. Inocencio, Danielle Warren, Gordon G. Wallace, Moeava Tehei, Anatoly B. Rosenfeld, Michael L.F. Lerch
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Synchrotron Radiation
Microbeam Radiation Therapy
Spatial fractionation
Bioprinting
Glioma
GelMA
Online Access:https://doi.org/10.1038/s41598-025-88793-9
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