Impact of Genetic Variation in Adrenergic Receptors on β-Blocker Effectiveness and Safety in Cardiovascular Disease Management: A Systematic Review
<b>Background/Objectives:</b> A systematic review was conducted to compile all the evidence on the impact of <i>ADRB1</i> and <i>ADRB2</i> genetic variants on the response to β-blockers, used for the management of cardiovascular diseases. <b>Methods:</b&g...
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MDPI AG
2025-03-01
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| Online Access: | https://www.mdpi.com/1424-8247/18/4/493 |
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| author | Houwaida Abbes Paula Soria-Chacartegui Asma Omezzine Francisco Abad-Santos Pablo Zubiaur |
| author_facet | Houwaida Abbes Paula Soria-Chacartegui Asma Omezzine Francisco Abad-Santos Pablo Zubiaur |
| author_sort | Houwaida Abbes |
| collection | DOAJ |
| description | <b>Background/Objectives:</b> A systematic review was conducted to compile all the evidence on the impact of <i>ADRB1</i> and <i>ADRB2</i> genetic variants on the response to β-blockers, used for the management of cardiovascular diseases. <b>Methods:</b> After searching in PubMed, PharmGKB, and the Cochrane Central Register of Controlled Trials including terms related to these drugs, genes, and pathologies, 1182 articles were retrieved, 29 of which met the inclusion criteria. A β-adrenoreceptor (ADRB) blockade qualitative variable was inferred for all the associations between genetic variants and clinical phenotypes. <b>Results:</b> The relationship between <i>ADRB1</i> rs1801253 (G>C) C allele and higher receptor blockade showed a moderate overall level of evidence, reaching a high level on its relationship with higher reduction in the systolic (SBP) and diastolic blood pressure and heart rate (HR). The relationship between <i>ADRB1</i> rs1801252 (A>G) G allele and lower receptor blockade reached an overall high level of evidence, considering its impact on the reduction in the SBP, HR, left ventricular end-diastolic diameter, and incidence of major cardiovascular events. The relationship between <i>ADRB2</i> rs1042714 (G>C) C allele and lower receptor blockade reached a moderate overall level of evidence due to its impact on HR, pulmonary wedge pressure, and left ventricular ejection fraction response. The <i>ADRB2</i> rs1042713 (G>A) A allele was associated with higher receptor blockade and higher HR reduction with a low level of evidence. <b>Conclusions:</b> The genotyping of both <i>ADRB1</i> variants may be clinically useful; further investigation is required on the relevance of both <i>ADRB2</i> variants. Further research is warranted to determine the clinical usefulness of <i>ADRB</i> preemptive genotyping. |
| format | Article |
| id | doaj-art-215c2f3a96fc41a5978dbf24e03785e7 |
| institution | OA Journals |
| issn | 1424-8247 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj-art-215c2f3a96fc41a5978dbf24e03785e72025-08-20T02:18:20ZengMDPI AGPharmaceuticals1424-82472025-03-0118449310.3390/ph18040493Impact of Genetic Variation in Adrenergic Receptors on β-Blocker Effectiveness and Safety in Cardiovascular Disease Management: A Systematic ReviewHouwaida Abbes0Paula Soria-Chacartegui1Asma Omezzine2Francisco Abad-Santos3Pablo Zubiaur4Clinical Pharmacology Department, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria La Princesa (IP), Universidad Autónoma de Madrid (UAM), 28049 Madrid, SpainClinical Pharmacology Department, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria La Princesa (IP), Universidad Autónoma de Madrid (UAM), 28049 Madrid, SpainBiochemistry Department, LR12SP11, Sahloul University Hospital, Sousse 4054, TunisiaClinical Pharmacology Department, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria La Princesa (IP), Universidad Autónoma de Madrid (UAM), 28049 Madrid, SpainClinical Pharmacology Department, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria La Princesa (IP), Universidad Autónoma de Madrid (UAM), 28049 Madrid, Spain<b>Background/Objectives:</b> A systematic review was conducted to compile all the evidence on the impact of <i>ADRB1</i> and <i>ADRB2</i> genetic variants on the response to β-blockers, used for the management of cardiovascular diseases. <b>Methods:</b> After searching in PubMed, PharmGKB, and the Cochrane Central Register of Controlled Trials including terms related to these drugs, genes, and pathologies, 1182 articles were retrieved, 29 of which met the inclusion criteria. A β-adrenoreceptor (ADRB) blockade qualitative variable was inferred for all the associations between genetic variants and clinical phenotypes. <b>Results:</b> The relationship between <i>ADRB1</i> rs1801253 (G>C) C allele and higher receptor blockade showed a moderate overall level of evidence, reaching a high level on its relationship with higher reduction in the systolic (SBP) and diastolic blood pressure and heart rate (HR). The relationship between <i>ADRB1</i> rs1801252 (A>G) G allele and lower receptor blockade reached an overall high level of evidence, considering its impact on the reduction in the SBP, HR, left ventricular end-diastolic diameter, and incidence of major cardiovascular events. The relationship between <i>ADRB2</i> rs1042714 (G>C) C allele and lower receptor blockade reached a moderate overall level of evidence due to its impact on HR, pulmonary wedge pressure, and left ventricular ejection fraction response. The <i>ADRB2</i> rs1042713 (G>A) A allele was associated with higher receptor blockade and higher HR reduction with a low level of evidence. <b>Conclusions:</b> The genotyping of both <i>ADRB1</i> variants may be clinically useful; further investigation is required on the relevance of both <i>ADRB2</i> variants. Further research is warranted to determine the clinical usefulness of <i>ADRB</i> preemptive genotyping.https://www.mdpi.com/1424-8247/18/4/493β-blockeradrenergic receptors<i>ADRB1</i><i>ADRB2</i>genetic variantblockade |
| spellingShingle | Houwaida Abbes Paula Soria-Chacartegui Asma Omezzine Francisco Abad-Santos Pablo Zubiaur Impact of Genetic Variation in Adrenergic Receptors on β-Blocker Effectiveness and Safety in Cardiovascular Disease Management: A Systematic Review Pharmaceuticals β-blocker adrenergic receptors <i>ADRB1</i> <i>ADRB2</i> genetic variant blockade |
| title | Impact of Genetic Variation in Adrenergic Receptors on β-Blocker Effectiveness and Safety in Cardiovascular Disease Management: A Systematic Review |
| title_full | Impact of Genetic Variation in Adrenergic Receptors on β-Blocker Effectiveness and Safety in Cardiovascular Disease Management: A Systematic Review |
| title_fullStr | Impact of Genetic Variation in Adrenergic Receptors on β-Blocker Effectiveness and Safety in Cardiovascular Disease Management: A Systematic Review |
| title_full_unstemmed | Impact of Genetic Variation in Adrenergic Receptors on β-Blocker Effectiveness and Safety in Cardiovascular Disease Management: A Systematic Review |
| title_short | Impact of Genetic Variation in Adrenergic Receptors on β-Blocker Effectiveness and Safety in Cardiovascular Disease Management: A Systematic Review |
| title_sort | impact of genetic variation in adrenergic receptors on β blocker effectiveness and safety in cardiovascular disease management a systematic review |
| topic | β-blocker adrenergic receptors <i>ADRB1</i> <i>ADRB2</i> genetic variant blockade |
| url | https://www.mdpi.com/1424-8247/18/4/493 |
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